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  "documentTitle": "Twist Bioscience (TWST)",
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      "text": "Twist samples lacked the necessary uniformity and quality control",
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      "text": "Twist samples lacked the necessary uniformity and quality control “Uniformity is the idea that if you count up the number of molecules of each sequence, you want approximately the same amount because when you do your experiment, you want an equal amount of testing for all of the different sequences that you sent...in this library, a portion of the sequences that we ordered were heavily underrepresented in the library...we haven’t ordered the next library to see if the same issue from January is still recurring. But we’ve ordered maybe seven of these really large pools, and it was the two in January that had the quality issue.” – Current Twist customer, professor with a protein therapeutics lab at a major university",
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      "text": "“Surprising” quality issues; Twist couldn’t fix them despite repeated attempts; almost “ruin[ed] our experiment” “We actually did have a surprising quality issue with Twist in January, and we still don’t totally understand it. We ordered an oligo pool, and on a few technical dimensions, the chemical material was not as uniform and high quality as when we were ordering last year. At first, it seemed like it was going to ruin our experiment, so we asked them to redo it, and they did, and then that second print was no better than the first, or maybe it was very slightly better than the first. And so, we went through a bunch of troubleshooting with them to try to understand what was going on. They were very accommodating as far as redoing things without charging us and talking to us to investigate all of the possible causes, but it didn’t actually get anywhere. But we figured out how to work with the lower quality material on our end. – Current Twist customer, professor with a protein therapeutics lab at a major university",
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      "text": "\"We actually did have a surprising quality issue with Twist in January, and we still don’t totally understand it... it seemed like it was going to ruin our experiment... they were very accommodating as far as redoing things without charging us and talking to us to investigate all of the possible causes, but it didn’t actually get anywhere.\" — Current Twist customer, professor with a protein therapeutics lab at a major university",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Large pharma players like Novartis, Abbvie, and leading genomics centers were not the only ones critical of Twist. Small, price-sensitive academic customers and biotech startups with lower quality requirements are Twist’s bread and butter – hooked by aggressive discounts and making-do with its commodity sequences – yet they highlighted similar dissatisfaction.",
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