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  "documentTitle": "TransMedics (TMDX)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-01-10 00:00:00",
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  "notes": "The slide uses expert testimonials to argue that the TransMedics device is 'fatally flawed' because it does not allow for functional assessment under load.",
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      "kind": "callout",
      "text": "30-40% of heart programs already moved to NRP; can assess the heart better with NRP",
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      "text": "Device is fatally flawed for heart as no pressure; NRP better",
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      "text": "The problem, compared to what you can do with NRP or other technologies, is that the heart on the TransMedics device is beating but it's empty...it's not doing any work...it's not supporting circulation...it's not generating a pressure.",
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      "text": "30-40% of heart programs in the US are now using NRP – you can assess the heart function completely...you're doing it in three to four minutes...you can assess all the normal physiologic parameters: is the heart beating again in the patient.",
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      "text": "After kidney and lung, we now discuss the heart product. Lung failed as cold storage is provably superior to warm perfusion – TransMedics entire premise was fatally flawed. Heart usage is in freefall for similar reasons: the pump is inferior to NRP in assessing heart function pre-transplant.",
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      "text": "The initial trials that TransMedics did were in conjunction with the guys from Cambridge in the UK... The problem, compared to what you can do with NRP or other technologies, is that the heart on the TransMedics device is beating, but it's empty.",
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      "text": "the problem, compared to what you can do with NRP or other technologies, is that the heart on the TransMedics device is beating but it's empty...it's not doing any work...it's not supporting circulation...it's not generating a pressure...",
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      "text": "My center is doing the same protocol that probably 30-40% of heart programs in the U.S. are doing now is we're using NRP... you can assess the heart function completely... you can assess all the normal physiologic parameters.",
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      "text": "\"The problem, compared to what you can do with NRP or other technologies, is that the heart on the TransMedics device is beating, but it's empty. It's not doing any work. It's not supporting circulation. It's not generating a pressure. So, you're guessing at that part, which is beating on the device based on the lactic acid level dropping, that it will function well enough that your recipient patient doesn't end up on ECMO or an Impella or on something else.\" — Prominent surgeon, director of leading academic transplant center; \"30-40% of heart programs in the U.S. are doing now is we're using NRP, normothermic regional perfusion... you can assess the heart function completely because you're putting the donor who's arrested, you're opening their chest and cannulating them and going on bypass rapidly, but you're doing it in three to four minutes... and you can assess all the normal physiologic parameters: is the heart beating again in the patient.\" — Prominent surgeon, director of leading academic transplant center",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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