{ "docId": "019dd923-622c-750b-8b9a-40e2965928db", "docSlug": "e5bffbaac707", "documentTitle": "TransMedics (TMDX)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "research-note", "documentKindLabel": "Research note", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-01-10 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 286, "pageCount": 342, "prevPage": 285, "nextPage": 287, "slideType": "expose_contradiction", "function": "expose_contradiction", "density": "overcrowded", "nDataPoints": 0, "notes": "The slide uses a Q&A format to highlight the gap between the device's intended utility and real-world clinical experience.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-40e2965928db/286", "deckHref": "/decks/019dd923-622c-750b-8b9a-40e2965928db", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-40e2965928db.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-40e2965928db#slide-286", "components": [ { "bbox": null, "kind": "callout", "text": "Surgeons provided devastating color that there is no correlation between how organs look on the pump and how they turn out in the recipient - that organs that look great may fail, and that organs which look questionable on the pump have performed fine.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-5373-719d-a988-9976ac1b17c8", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.85, "x": 0.07, "y": 0.65 }, "kind": "list", "text": "No correlation between organ performance on pump and after transplant", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "2a19557c-6a9e-451f-9e75-c8fb4bcbeea2", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.85, "x": 0.07, "y": 0.19 }, "kind": "paragraph", "text": "Surgeons provided devastating color that there is no correlation between how organs look on the pump and how they turn out in the recipient – that organs that look great may fail, and that organs which look questionable on the pump have performed fine.", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "02243662-4325-43ea-81ac-6896570a0eca", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.85, "x": 0.07, "y": 0.34 }, "kind": "paragraph", "text": "A liver transplant surgeon who runs a major program stated no one knows how to use the machine data, indicating cases where “the data from the machine has been good, but we have a liver that it not good in the end...so we don’t have perfect data to tell us whether a liver is going to be good or not.”", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "aaae19c5-1845-4fee-8ede-d66d2cfca58e", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.85, "x": 0.07, "y": 0.49 }, "kind": "paragraph", "text": "He noted the confusion exists despite almost a decade of study and use since the clinical trials started – “there’s still not enough data that can tell us when something’s good...so you get a lot of surgeon cross-talk....’What should I do? Should I give it more time? Should I dump it?’....we’re still trying to sort that out.”", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "fb7c58d2-3e76-48c5-bf68-ec7a2a47e08c", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.85, "x": 0.07, "y": 0.78 }, "kind": "quote", "text": "Q: “I talked to a cardiac transplant surgeon. He also said that there’s no correlation between how well a heart pumps, how it looks once you put it on the pump versus what ends up happening when you implant it. So, they’ve seen cases where it didn’t look good at all, and it ended up being great, and cases where it looked great, and it was a disaster. Is that what you’re observing?”", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "83e9a776-7f53-4e93-9ba6-0bee94bf1428", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.1, "w": 0.85, "x": 0.07, "y": 0.68 }, "kind": "quote", "text": "A: “They have a specialist that’s with the machine and the organ at all times and you’re checking labs hourly. And so it requires a lot of manpower to manage. I would say that we’ve had a few cases where all of the data from the machine has been good, but we still have a liver that is not good in the end. And so we don’t have perfect data to tell us whether a liver is going to be a good liver or not..”", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "8b15a3d8-f2b8-4b38-ad6d-5cebc37b5d2b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.1, "w": 0.85, "x": 0.07, "y": 0.86 }, "kind": "quote", "text": "A: “Yeah, I would say that is true and it’s such a novel device even though it’s been out and we’ve had a trial and everything. There’s still not enough data that can tell us when something’s good or not. And so, you get a lot of surgeon cross-talk, people talking to one another, high-volume users saying I’ve got this scenario on the device. Would you use that? Or what would you do? What should I do? Should I give it more time? Should I dump it? I think we’re still trying to sort that out...” - Transplant surgeon at a high-volume West Coast academic center", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "c68a5513-3751-4ed8-8159-27292f53fcde", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“the data from the machine has been good, but we have a liver that it not good in the end...so we don’t have perfect data to tell us whether a liver is going to be good or not.” — Transplant surgeon at a high-volume West Coast academic center", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-5373-719d-a988-9d30a24c4a5b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.3, "x": 0.07, "y": 0.97 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "edc59d55-16c1-4157-bc58-2487164ab8f8", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.12, "w": 0.85, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Both heart/lung and liver transplant surgeons undermined the fundamental premise of the pump", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "299c45ad-619f-45b3-9540-fdaba7b0f756", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }