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  "notes": "The slide uses excerpts from clinical literature to define the risks of transplanting steatotic livers.",
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      "text": "Clinical literature on steatotic liver outcomes – Transplantation journal, 2020 and 2023 papers",
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      "text": "The clinical literature is unequivocal, per another study: \"steatotis in the donor liver has been identified as a predictor of graft failure...so these livers are often considered...marginal....\"",
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      "text": "The third labeled criteria for OCS Liver is ≤15% macrosteatotis, which refers to a low level of fat accumulation, as even mild levels of liver fat ~5% pose risks, while levels >20-30% lead to substantially higher levels of transplant failure.",
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      "text": "Donor livers with ≥30% macrosteatosis (steatotic livers) represent a possible expansion to the donor pool, but are frequently discarded as they are associated with an increased risk of mortality and graft loss. We hypothesized that there are certain recipient phenotypes that",
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      "text": "Macrovesicular steatosis in the donor liver has been identified as a predictor of graft failure, and so these livers are often considered extended criteria or marginal livers.2 Previous studies have demonstrated an association",
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      "text": "One study found 2-3-fold higher odds of death in patients receiving macrosteatotic livers versus those with non-steatotic grafts. Livers with 30% macrosteatosis are “frequently discarded as they are associated with an increased risk of mortality and graft loss. The clinical literature is unequivocal, per another study: “steatotis in the donor liver has been identified as a predictor of graft failure...so these livers are often considered...marginal....”",
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      "text": "“frequently discarded as they are associated with an increased risk of mortality and graft loss.” — Transplantation journal",
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      "kind": "source-note",
      "text": "Source: Scorpion Capital consultation calls with experts; https://pmc.ncbi.nlm.nih.gov/articles/PMC7237292/; https://srtr.org/media/1617/kwong-transplantation-2023-impact-of-donor-liver-macrovesicular-steatosis-on-deceased.pdf",
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      "kind": "title",
      "text": "Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome",
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      "kind": "title",
      "text": "Minimizing Risks of Liver Transplantation With Steatotic Donor Livers by Preferred Recipient Matching",
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