{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 96, "pageCount": 415, "prevPage": 95, "nextPage": 97, "slideType": "nominee_bio", "function": "introduce_nominees", "density": "dense", "nDataPoints": 0, "notes": "The slide presents a qualitative critique from a medical professional, highlighting skepticism regarding clinical efficacy and administrative burden.", "elementsJson": [ "headline_text", "bullet_list", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/96", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-96", "components": [ { "bbox": null, "kind": "callout", "text": "I don't believe it is that powerful or effective to begin with", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b29d-ab8d10520428", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.13, "w": 0.86, "x": 0.07, "y": 0.8 }, "kind": "list", "text": "Stated diazoxide is “old news” and that he would “switch everybody over to the generic anyway” if he thought it had any benefit in PWS: “it’s not particularly powerful...diazoxide is not, in and of itself, a brand-new medication...it’s a drug that we’ve used in other disease states for years...the actual drug has been approved for many years to be used in other diseases...many people have been put on it previously...we actually know this stuff pretty well because it’s a drug that’s been out for a while....”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "06b9451c-da1a-4735-b7c3-2ea832f125b8", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.35, "w": 0.86, "x": 0.07, "y": 0.21 }, "kind": "list", "text": "Extremely skeptical of Vykat, “I’m better read than average”: no start forms submitted, families are disinterested/hesitant; clinical data is “underwhelming” with a history of failed trials and no hard endpoint; “old news” as endocrinologists are very familiar with diazoxide and don’t view it as novel, and would just use generic suspension instead anyway; thinks “severity of edema and cardiac risk is probably being underplayed” and is “real and significant”; worries about diabetes risk; is unwilling to invest administrative time to push for insurance approval as “I don’t believe it is that powerful or effective to begin with” and “not worth it to fight super hard” – “I don’t have anybody who’s actually started it...one of my patients...we’ve had a discussion...but the family wanted to...think about it first...some of them are going to be intrigued with any new options, and others are going to be a little more hesitant.”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "813ddefa-2305-433c-8147-77d7b546c2b4", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.22, "w": 0.86, "x": 0.07, "y": 0.57 }, "kind": "list", "text": "Slammed Vykat on all counts, stating the studies were “a little underwhelming” and failed to show weight reduction or a proper endpoint – and that he wouldn’t push it patients: “if the goal here is largely appetite, weight, that sort of zone, at least show a benefit in BMI or something...those are the typical endpoints that we use...in this space”; “the data is not so strong with this medication that we’re going to push hard”; “while the medicine is approved and there are not a lot of options in PWS, it’s not like the data was like so strong...the drug had to fight hard to get approved...it failed at initial trial and had to get a second bite at the apple...it’s not some world-changingly powerful medication.”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "b8ec971c-d3a1-4e56-a40c-1184cdcf3f72", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“if the goal here is largely appetite, weight, that sort of zone, at least show a benefit in BMI or something...those are the typical endpoints that we use...in this space” — PWS endocrinologist #9", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b29d-af8a009cc90c", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.3, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "f2b49562-d846-4612-869b-28ced9009090", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.12, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "PWS endocrinologist #9: In private practice in a major Texas metropolitan area with 4 endocrinologists and personally manages 5 PWS patients.", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "c29b7553-8030-4716-8c4b-e7aa7f8ac046", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }