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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "This slide presents qualitative feedback from a medical expert, highlighting significant barriers to adoption for the drug Vykat.",
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      "text": "The center’s lack of interest in meeting the Soleno rep was striking – “I don’t see that scheduled in any near future, to be honest with you”",
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      "text": "The center’s lack of interest in meeting the Soleno rep was striking – “I don’t see that scheduled in any near future, to be honest with you” – and expressed surprise that diazoxide was even studied as indication for PWS.",
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      "text": "No patient start forms submitted at the institution and indicated high skepticism of Vykat with no interest in meeting Soleno drug rep. Stated that diazoxide is an old compound well-known to endocrinologists, with risk of diabetes, edema, and heart failure.",
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      "text": "The endocrinologist was ambivalent and apprehensive about the amount of time required to manage insurance denials, given the extreme price; and described a dysfunctional commercial launch.",
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      "text": "“We are going to wait...we are going to wait...we have not met with their medical science liaison”; “as pediatric endocrinologists, we are familiar with the short-acting form of diazoxide...we have used that for quite some time...with congenital hyperinsulinism.... side effects that have been a concern...it mostly may present as a lymphedema versus congestive heart failure”; “hyperglycemia...we know that diazoxide causes it.”; “I’m not sure if they have field people...and help and explain...we are not going to reach out to our patient population”; “only one family came forward...not a big push...pretty quiet...some people were quite surprised within our division...it came actually as a surprise that this drug is in a trial...prior to FDA approval, there was not much noise about it.”; “how is that going to pan out if we get denial after denial after denial...so it doesn't consume too much of our time...if the internal medicine specialist says, sorry, it's too expensive of a drug, and I don't see really a benefit for that. I don't know...”; “it's a little bit unclear to us what's happening here”; “I don't know whom they are targeting and how....” — PWS endocrinologist #8",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "PWS endocrinologist #8: At a “children's hospital that's affiliated with a medical academic center and medical school” in the southeast US; and has 5 PWS patients personally.",
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