{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 93, "pageCount": 415, "prevPage": 92, "nextPage": 94, "slideType": "nominee_bio", "function": "introduce_nominees", "density": "dense", "nDataPoints": 2, "notes": "The slide presents qualitative feedback from a medical expert, highlighting concerns about diabetes risk and comparing the drug to the Aduhelm controversy.", "elementsJson": [ "headline_text", "bullet_list", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/93", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-93", "components": [ { "bbox": null, "kind": "callout", "text": "Compared Vykat to the Aduhelm debacle as taking on a tremendous risk for dubious benefit, and concurred when we asked why anyone would prescribe the drug vs. generic diazoxide.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b29d-4f5a3895ea6f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.35, "w": 0.85, "x": 0.07, "y": 0.52 }, "kind": "list", "text": "Compared Vykat to the Aduhelm debacle as taking on a tremendous risk for dubious benefit, and concurred when we asked why anyone would prescribe the drug vs. generic diazoxide, stating that an oral suspension is obviously superior in pediatrics vs. tablets – “I don't think you're wrong...I think there are probably more questions than answers”; “a perfect example is the Alzheimer's drug... the risk of CNS bleeding... there are other drugs that are being looked at [for PWS]...if we're looking for a magic bullet, this isn't magic, and it's not a targeted bullet”; “of course, we would want to use an oral suspension...we're pediatricians - liquids rock....”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "4a868441-d63f-4963-bf8f-4a23c29b751c", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.35, "w": 0.85, "x": 0.07, "y": 0.16 }, "kind": "list", "text": "Troubled by a recent conversation with Jennifer Miller regarding diabetes risk, opining that she wasn't optimistic about Vykat in private – “she wasn't sanguine”; “she's aggressive and a little out there in regards to therapies” – and believed that she took a teenage patient off the drug due to diabetes, calling it “weird” – “what she did tell me...is that she had a patient who was developing diabetes...she was going to stop the medication...that's the weird thing...because she thought that with other interventions that she had an armamentarium...that they can get rid of the diabetes...my concern having treated plenty of kids with diazoxide for hyperinsulinism is what's the glycemic issues...again...this n of one was very interesting, that Jennifer Miller said, hey, treat the diabetes...”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e49f5b3b-7507-40a4-a85d-64bea4ab36f6", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“she wasn't sanguine”; “she's aggressive and a little out there in regards to therapies”; “what she did tell me...is that she had a patient who was developing diabetes...she was going to stop the medication...that's the weird thing...because she thought that with other interventions that she had an armamentarium...that they can get rid of the diabetes...my concern having treated plenty of kids with diazoxide for hyperinsulinism is what's the glycemic issues...again...this n of one was very interesting, that Jennifer Miller said, hey, treat the diabetes...”; “I don't think you're wrong...I think there are probably more questions than answers”; “a perfect example is the Alzheimer's drug... the risk of CNS bleeding... there are other drugs that are being looked at [for PWS]...if we're looking for a magic bullet, this isn't magic, and it's not a targeted bullet”; “of course, we would want to use an oral suspension...we're pediatricians - liquids rock....” — Pediatric endocrinologist and Division Chief", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b29d-505d9a18b720", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.25, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "9e7cc576-5d50-4a14-97d2-b150f0fa713a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.85, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Endocrinologist #7 (cont'd): Pediatric endocrinologist and Division Chief at a major academic center; 20 PWS patients historically and 3-5 currently.", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "07d3c912-33c0-4679-b6ec-f82b8effef5c", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }