{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 91, "pageCount": 415, "prevPage": 90, "nextPage": 92, "slideType": "testimonial", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide uses direct quotes to highlight expert skepticism regarding safety, efficacy, and pricing.", "elementsJson": [ "headline_text", "bullet_list", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/91", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-91", "components": [ { "bbox": null, "kind": "callout", "text": "at this point, nobody is really saying this is something we absolutely should be doing...the company thinks it's the best thing since sliced bread...you know what?...we are going to do our standard of care...we're not going to start it day one.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b29c-ba218d871c1f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.18, "w": 0.85, "x": 0.07, "y": 0.75 }, "kind": "list", "text": "Unequivocally rejected diazoxide as an old, well-known drug with tremendous safety problems and was baffled that its now being tried in PWS – “we’ve all used it...I used it in the early ’90s and saw the hypertrichosis, which was very, very bad in young women...there are also actually some jaw changes that occur with prolonged use...and it is a drug, not without risk...they’re a one-trick pony at this point...I don’t know what the genesis of the idea for the drug was...I have no idea where this came from, why there were some original trials or thoughts about it...but as I said, at this point, am I going to use it? No, I’m not going to use it.”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "6387a365-d0b2-4069-9d19-0c0f36eebdf7", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.85, "x": 0.07, "y": 0.16 }, "kind": "list", "text": "Recently reviewed Vykat papers at a “journal review” with 8 endocrinology colleagues – stated that they were all highly skeptical of Vykat with no plans to prescribe; called Soleno a “one-trick pony” and was bewildered anyone would think to use diazoxide in PWS patients, dismissing Vykat as “bananas” and “Mickey Mouse”; extreme concern about diabetes, cardiac events, and fatal DKA; compared it to the Aduhelm debacle; and stated that generic diazoxide suspension is superior to Vykat’s tablet format – “more questions than answers.” He added that he spoke with Jennifer Miller at a recent conference – “obviously, they were trying to educate/sell the drug” - and that no families have asked about Vykat – “we’re not hearing a bunch” – and that they’ve refused to meet the drug rep – “they’d like to, but we’ve got limited time...”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "6fe6526e-c89a-45dc-b7d1-98b33b3c8005", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.32, "w": 0.85, "x": 0.07, "y": 0.42 }, "kind": "list", "text": "Stated that the 8 endocrinologists at the recent Vykat journal review thrashed the drug and dismissed Soleno’s claims, and viewed the price as “bananas” for a disease that’s inexpensive to treat with diet and other interventions: “we sat around the table reading the article...the specific things that we talked about were diabetes and cardiac risk...at this point, nobody is really saying this is something we absolutely should be doing...the company thinks it’s the best thing since sliced bread...you know what?...we are going to do our standard of care...we’re not going to start it day one.” He contrasted it with other rare diseases where “we started the new meds right away” because they had “the utmost respect for some of the investigators” and “the safety profile was really good” – implying that Vykat was not like these other medications. He added: “that price is bananas because the disease isn’t that expensive...and other interventions do make a big difference.”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "9d8ff18c-0120-49e0-bc7e-fba3212b7aa7", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "they were all highly skeptical of Vykat with no plans to prescribe; called Soleno a “one-trick pony” and was bewildered anyone would think to use diazoxide in PWS patients, dismissing Vykat as “bananas” and “Mickey Mouse” — Endocrinologist #7.", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b29c-bf2ac60662b4", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.3, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "3cca152e-a338-4c1e-9d2a-3bbeb0a8db20", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.85, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Endocrinologist #7: Pediatric endocrinologist and Division Chief at a major academic center, with 20 PWS patients historically and 3-5 currently.", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "a5f5fdb5-9525-4220-b3cc-22411b3b2627", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }