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      "text": "the downside...is hyperglycemia and maybe some of the peripheral edema, fluid retention, maybe exacerbating some heart failure",
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      "text": "Concerned about inducing diabetes and heart failure from edema and thinks it’s inherent to diazoxide’s mechanism of action; potentially fatal side effects from DKA; prevalence of diabetes in PWS patients shrinks the TAM – “the downside...is hyperglycemia and maybe some of the peripheral edema, fluid retention, maybe exacerbating some heart failure”; “doesn't take much to make them diabetic...no surprise, given this mechanism of action...no surprise...and importantly, some patients get ketoacidotic because the insulin suppression is so potent at these doses that you essentially render the patient to be type-one diabetic...which could be potentially lethal in wide use”; “probably 40% of my patients with Prader-Willi, even at this young age, already have diabetes...I'll be especially leery about introducing diazoxide into a diabetic patient...important limitation on the overall kind of access to an already rare disease.”",
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      "text": "“the downside...is hyperglycemia and maybe some of the peripheral edema, fluid retention, maybe exacerbating some heart failure”; “doesn't take much to make them diabetic...no surprise, given this mechanism of action...no surprise...and importantly, some patients get ketoacidotic because the insulin suppression is so potent at these doses that you essentially render the patient to be type-one diabetic...which could be potentially lethal in wide use”; “probably 40% of my patients with Prader-Willi, even at this young age, already have diabetes...I'll be especially leery about introducing diazoxide into a diabetic patient...important limitation on the overall kind of access to an already rare disease.” — PWS endocrinologist #1",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "PWS endocrinologist #1 (cont'd): Affiliated with Northwestern University",
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