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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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      "text": "it's pretty quiet overall... what I'm not hearing people say, when can I get my hands on Vykat? Because we all know diazoxide, and we all know the problems with it. It's not like we're clueless.",
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      "text": "Intensely skeptical of the trial data – “that’s rubbish” – and bewildered and surprised that Vykat even got approved; endocrinology field doubted “that this was likely to happen...me and my colleagues were surprised that all of a sudden we have an approval with this label right now – “I wasn't anticipating this particular piece of news...I wasn't expecting to see this — I don't think there was a perspective that this was likely to happen”; “it's been an erratic performer in trials, and I think I was comparatively unimpressed by — and somewhat inattentive as a result — to the journey of diazoxide through the trials... not particularly exciting and therefore kind of lost interest... when I saw this approval, I was like, \"What the hell?\" I wasn't expecting that”; “I do remember looking at one of the — I think it was an investor deck...where they were talking about why this works. And I was like, \"That's rubbish.\"",
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      "text": "Surprised Vykat received FDA approval and indicated no enthusiasm for Vykat among physicians or patients – “it’s pretty quiet overall... what I'm not hearing people say, when can I get my hands on Vykat? Because we all know diazoxide, and we all know the problems with it. It's not like we're clueless. I'll put it this way...this somewhat surprising and out of the blue approval that I don't think any of us were quite expecting.”",
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      "text": "Zero emails from PWS patients inquiring about Vykat; if Vykat were theoretically useful, he would quickly put them on generic diazoxide suspension anyway; questions “whether this is all hoopla and bluster”; is “furious” about the price and finds it “outrageous” – “it bothers me, it makes me mad” as appetite suppression can be obtained for “pennies” with other medications – “I haven't had emails from my patients or patients' families, which is very interesting, even though this is a pretty active community. So, that's just interesting, but I haven't, and that's maybe telling”; “a lot will come off the branded version onto generic if it works”; “appetite suppression could be readily achieved with sedating medications like Haldol and other antipsychotics, for example, which have their own diabetogenic risk for the cost of pennies.”",
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      "text": "\"it's pretty quiet overall... what I'm not hearing people say, when can I get my hands on Vykat? Because we all know diazoxide, and we all know the problems with it. It's not like we're clueless. I'll put it this way...this somewhat surprising and out of the blue approval that I don't think any of us were quite expecting.\" — PWS endocrinologist #1; \"that's rubbish\" — PWS endocrinologist #1",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "PWS endocrinologist #1: Affiliated with Northwestern University and a community hospital which collectively manage 50% of PWS patients in the Chicago area and in touch with those who manage the rest; approximately 20 patients and personally sees 8 to 12 annually.",
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