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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "the actual active drug smelled a bit, and it smelled differently from the placebo...and the message went around, and people could tell that it was the active drug.",
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      "text": "Noted various red flags in the trials – “distortions” – such as unblinding. He stated that all his enrollees were on active drug, which he was able to deduce; and that families knew if they were on drug on placebo as the Vykat tablet has a smell – “the actual active drug smelled a bit, and it smelled differently from the placebo...and the message went around, and people could tell that it was the active drug.” He was further skeptical of the purported improvements reported in Soleno’s trials – “those improvements happening late into the trial and in the open phase...if the improvement is fundamentally happening in the open phase, then that’s problematic.”",
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      "text": "Stated that he had to “pause one person whose blood sugar levels got a bit out of control” and expressed concern at Vykat’s diabetes risk profile – “here’s a population that is very at risk of diabetes...here, in a way, you’ve got the worst of both worlds...you’ve got a drug that doesn’t seem to very effective in controlling hyperphagia, and it has a risk of elevating blood sugars.”",
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      "text": "Stated that investigators were kept in the dark and that Soleno was overly “secretive” – “we didn’t see much of the data...it was presented more to us as one might...in a paper or presentation...a sort of group data...we didn’t get feedback on our own individual participants...more secretive than they should have been.”",
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      "text": "“the actual active drug smelled a bit, and it smelled differently from the placebo...and the message went around, and people could tell that it was the active drug.” — Trial investigator #3",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "kind": "title",
      "text": "Trial investigator #3 (cont’d): Longtime, globally-recognized authority on Prader-Willi Syndrome",
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