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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "Vykat’s mechanism of action is fundamentally incompatible with PWS patient physiology from a safety standpoint",
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      "text": "Extremely concerned about diabetes, cardiac, and neurological safety signals... Extreme level of concern at potential channelopathy defects... Vykat's mechanism of action is fundamentally incompatible... Stated that a quarter of PWS patients have a genetic subtype incompatible... Stated that Vykat's tendency to induce edema magnifies risk... Additional fear about Vykat-induced diabetes... Dismissed the trials as fatally flawed due to a subjective endpoint",
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      "text": "“No, I won’t [use it] because of Zafgen...we find out oh, six months from now...they all of a sudden have cardiomyopathy or seizures....I’m concerned about safety.” — Trial investigator #1",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #1 (cont’d): One of the most prominent, published, and influential authorities in Prader Willi Syndrome",
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