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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a 'smoking gun' narrative to allege data fabrication by comparing two sets of longitudinal clinical trial data.",
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      "text": "And thus Soleno and Gevers, Miller et al are caught red-handed: the new dataset contains both HbA1c and fasting glucose charts, but it appears they forgot to alter the fasting glucose one - which shows the new HbA1c data is a fabrication.",
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      "text": "FIGURE 2: Mean Fasting Plasma Glucose (mg/dL) by Week of DCCR Administration",
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      "text": "MEAN (SE) HBA1C OVER TIME",
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      "text": "FIGURE 1: Mean Hemoglobin A1C (%) by Week of DCCR Administration",
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      "text": "To hide a lie a thousand lies are needed - and culprits eventually get sloppy. The original, correct dataset (2024) includes a graph for both HbA1c and fasting plasma glucose. Since fasting plasma glucose relates directly to HbA1c, we can calculate the corresponding HbA1c for the fasting glucose timepoints presented to see which HbA1c graph is correct. And thus Soleno and Gevers, Miller et al are caught red-handed: the new dataset contains both HbA1c and fasting glucose charts, but it appears they forgot to alter the fasting glucose one – which shows the new HbA1c data is a fabrication.",
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      "text": "Source: https://investors.soleno.life/presentations/scientific-posters-presentations; https://investors.soleno.life/static-files/7c732b67-56dc-4959-ac2f-31543a7c0ca3; Scorpion Capital analysis and estimates",
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      "text": "Comparing the HbA1c and fasting glucose data sets between the two publications provides a second smoking gun.",
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