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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses visual evidence to argue for data fabrication in a clinical trial report.",
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      "kind": "callout",
      "text": "Scale warp - note the stretched out HbA1c axis in the top graph vs original. This makes the SEM's appear more like the original graph in relative perspective",
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      "text": "The mean HbA1c line is moved upward, thereby moving the population into pre-diabetic range (HbA1c > 5.7%). We added a red line to show pre-T2D cut off.",
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      "text": "Thus, we conclude it is fabricated data – a sloppy, amateur cut-and-paste job.",
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      "text": "Bottom chart: Figure 1: Mean Hemoglobin A1C (%) by Week of DCCR Administration",
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      "text": "Top chart: Mean (SE) HbA1c over time",
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      "text": "HbA1c levels: 5.7%",
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      "text": "The original graph showed baseline HbA1c levels well below pre-diabetes range, at the start of the phase 3 trial. The second graph moves the line up, thus shifting the population's baseline HbA1c levels into pre-diabetic zone.",
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      "text": "The reason, we infer, is subtle but nefarious, as we cover in a later chapter: we think the best way to hide that your drug made a substantial portion of Phase 3 patients pre-diabetic or diabetic over 13 weeks is by claiming they were pre-diabetic to begin with.",
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      "text": "Source: https://investors.soleno.life/presentations/scientific-posters-presentations; https://investors.soleno.life/static-files/7c732b67-56dc-4959-ac2f-31543a7c0ca3",
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