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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "sourceTypeLabel": "Short seller",
  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a specific chart from a clinical paper to challenge the safety profile of the drug.",
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      "text": "We presume the purported safety data tipped the balance, and therein lies the rub: the safety data obscured the risks in a manner we find to be nefarious.",
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      "kind": "chart",
      "text": "Figure 2. LS Mean (± SE) Increase in Lean Mass (kg) from Baseline",
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      "text": "Long-term Administration of Diazoxide Choline Extended-Release (DCCR) Tablets in People with Prader-Willi Syndrome: Changes in Lean Body Mass and Lean Mass Index",
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      "text": "Lean Body Mass (kg): 7.3",
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      "text": "The obvious question – how did a drug this obviously toxic get through the FDA? The agency was poised to do the sensible thing and reject it after the phase 3 failed, relenting after a high-pressure, orchestrated petition campaign to allow Soleno to proceed with a highly unusual 16-week randomized withdrawal study. We presume the purported safety data tipped the balance, and therein lies the rub: the safety data obscured the risks in a manner we find to be nefarious. Let’s start with the risk of fluid retention. The key data is contained in a May 2025 paper. Jennifer Miller is the lead author. The paper shows a linear increase in lean body mass (LBM) over 3 years of 7.3 kg or 16 lbs.",
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      "text": "Source: https://investors.soleno.life/static-files/946b0269-ce30-4c6f-943c-8fa4ed54f44a; Scorpion Capital analysis and estimates",
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      "text": "Chart from Soleno paper – May 25, 2025",
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