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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses strong, accusatory language ('hoax', 'scientifically unfounded', 'misleading') to attack the target company's scientific rationale.",
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      "text": "If a drug does the exact opposite of what it claims, has potentially fatal adverse effects, and bills you $500K for the favor, it's a hoax.",
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      "text": "Review\nThe Potential Role of Activating the ATP-Sensitive Potassium Channel in the Treatment of Hyperphagic Obesity\nNeil Cowen * and Anish Bhatnagar",
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      "text": "We don't think VYKAT XR reduces hyperphagia – the evidence strongly indicates it backfires and *increases* hunger and *lowers* satiety via insulin suppression and insulin resistance. If a drug does the exact opposite of what it claims, has potentially fatal adverse effects, and bills you $500K for the favor, it's a hoax. VYKAT XR purports to reduce hyperphagia via a CNS-mediated hypothalamic mechanism that is pharmacologically implausible, per a contrived 2020 paper by Soleno's Cowen and Bhatnagar. We have a mini-deck just on this topic which we couldn't clean up for today. So we'll keep it simple: overwhelming scientific evidence indicates that diazoxide does not cross the blood-brain-barrier. Its physiochemical properties favor CNS exclusion, with 3 key factors that block passive diffusion into the brain from either blood or CSF: 1) diazoxide is highly polar; 2) poorly lipophilic; and 3) >90% bound to albumin. Thus, VYKAT cannot reach central KATP channels in the brain, rendering the CNS-target rationale for PWS both scientifically unfounded and misleading.",
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      "text": "Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC7230375/pdf/genes-11-00450.pdf",
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