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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a Q&A format to highlight internal skepticism regarding clinical trial data.",
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      "text": "“They were just surprised to see that it was so extreme, especially given the fact that it seemed to happen so quickly after they came off the drug. They didn’t expect that. They expected it to be a slower withdrawal [...]”",
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      "text": "Q: “I’ve heard from several investigators that the trial was functionally unblinded because 30% to 40% of patients have a side effect of rapid hair growth. Now, if I look at that withdrawal study, the increase in the HQ-CT score for the placebo patients was so sharp, rapid, and extreme, it actually strains credibility, to be candid with you.”\nA: “I know. I hear you, because that was a conversation that was had internally. But it was the data that it was, and they moved forward with it.”\nQ: “What was the conversation internally? They didn’t believe the data? They thought it was too good to be true?”\nA: “They were just surprised to see that it was so extreme, especially given the fact that it seemed to happen so quickly after they came off the drugs. They didn’t expect that. They expected it to be a slower withdrawal [...].”\nQ: “Were there people inside the company when they saw the randomized withdrawal data, did they really believe it? But they’re like, whatever, it’s the data, we’ve got to take it?”\nA: “Well, so much of the data is subjective. It’s a subjective opinion.” - Formerly in a senior medical affairs role at Soleno",
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      "text": "Not surprisingly given the withdrawal study’s dependence on one site with a rather enthusiastic champion of the drug, the ex-employee indicated that even Soleno was “surprised” at how “extreme” the spike in HQ-CT scores was in the placebo arm which compared the change vs. those who remained on drug – we emphasize the placebo group’s increase in hyperphagia scores is the basis of FDA approval – “that was a conversation that was had internally…but it was the data that it was…they were just surprised to see that it was so extreme, especially given the fact that it seemed to happen so quickly after they came off the drug…they didn’t expect that…they expected it to be a slower withdrawal.”",
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      "text": "“I know. I hear you, because that was a conversation that was had internally. But it was the data that it was, and they moved forward with it.” — Formerly in a senior medical affairs role at Soleno",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Soleno was allegedly surprised at “extreme” withdrawal study data – “they didn’t expect that”",
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