{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 410, "pageCount": 415, "prevPage": 409, "nextPage": 411, "slideType": "expose_contradiction", "function": "expose_contradiction", "density": "overcrowded", "nDataPoints": 0, "notes": "The slide uses Q&A transcripts to highlight the expert's skepticism regarding Vykat's value proposition.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/410", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-410", "components": [ { "bbox": null, "kind": "callout", "text": "I'm very, very familiar with that", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64cf-7128-a313-f2ded541c755", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.05, "w": 0.86, "x": 0.07, "y": 0.33 }, "kind": "list", "text": "Views Vykat and generic diazoxide as substitutable similar to other expensive drugs with generic options – “I’m very, very familiar with that”", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "7e45dc64-417e-4f8a-b9f3-27d4d503aa73", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.05, "w": 0.86, "x": 0.07, "y": 0.63 }, "kind": "list", "text": "Endocrinologist was independently questioning the need for Vykat given the existence of generic diazoxide; GLP’s already being imported cheaply from countries with price caps", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e88ae721-6c1e-47c1-b1f4-ad30036b2c51", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.22, "w": 0.86, "x": 0.07, "y": 0.68 }, "kind": "paragraph", "text": "A: “It’s a shorter half-life also?”\nQ: “They’re both just diazoxide so presumably similar half-life once in plasma.”\nA: “Oh, it is the same half-life.”\nQ: “Why would anybody use a half-million to $1,000,000 tablet versus an inexpensive oral suspension that also seems safer?”\nA: “I agree...the idea, and I was going to bring that up even at the onset, the fact that we have a generic. I don't know if you're aware that's going on with the GLP-1s all the time right now, that they're getting it from out of the country. There are companies now that are importing it from England. They have price caps on it, so it's much, much cheaper.” – Endocrinologist based in NYC, 15 PWS patients", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "880c25ce-9832-4e5f-bf0b-32c115c1c38b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.22, "w": 0.86, "x": 0.07, "y": 0.38 }, "kind": "paragraph", "text": "Q: “I had a PhD in pharmacokinetics look at the few shreds of PK data that Soleno has been willing to publish, because I think they're scared about the fact that they are basically equivalent pharmacokinetically. And the only reason they did an extended-release formulation is because there's a generic. There's no clinical rationale for it.”\nA: “Correct. Unfortunately, that's not uncommon. Take a look at the weight loss drugs Contrave and Qsymia which have generics. And we do that all the time for patients for weight loss and we just put them on the generic, and it cost them almost nothing as opposed to — it's nowhere near what Vykat cost, but it's the same idea. I'm very, very familiar with that.” – Endocrinologist based in NYC, 15 PWS patients", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e1c1a176-d0e4-4478-80ed-1275c6ff3975", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "Correct. Unfortunately, that's not uncommon. Take a look at the weight loss drugs Contrave and Qsymia which have generics. And we do that all the time for patients for weight loss and we just put them on the generic, and it cost them almost nothing as opposed to — it's nowhere near what Vykat cost, but it's the same idea. I'm very, very familiar with that. — Endocrinologist based in NYC, 15 PWS patients", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64cf-7128-a313-f6643c757166", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.3, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "dd57c682-4fec-4956-8054-fd6b7b5fc3a7", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "The endocrinologist was already wondering if Vykat could be substituted with generic diazoxide suspension, and stated he is “very familiar” with using generic formulations off-label instead – “Unfortunately, that's not uncommon...take a look at the weight loss drugs Contrave and Qsymia which have generics...and we do that all the time for patients for weight loss and we just put them on the generic, and it cost them almost nothing...it's nowhere near what Vykat cost, but it's the same idea....I'm very, very familiar with that”; “I was going to bring that up even at the onset, the fact that we have a generic....”", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "5001d6e2-3124-4bfa-a76b-c15667f56b86", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }