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  "notes": "The slide uses a 'villain' framing to question the validity of Soleno Therapeutics' clinical trial results.",
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      "text": "A winning sprint at the finish line is suspicious, raising concern of data fabrication.",
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      "text": "C602 RWP HQ-CT Total Score at Week 16 Change from Baseline for DCCR Compared to Placebo",
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      "text": "p-value: 0.049",
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      "text": "A winning sprint at the finish line is suspicious, raising concern of data fabrication. Thus, we see a squeaker of a p-value of 0.049 in week 12 - a touch below the 0.05 threshold for statistical significance.",
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      "text": "What you see below is the pathetic data that is the basis of FDA approval, the rationale for a $500K drug with reports of kids in the ICU: a sudden separation of scores on a highly subjective caregiver survey in the final 16th week of the study.",
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      "text": "In the absence of a published manuscript for the pivotal withdrawal study, the public and holders of the stock are flying blind. They have no idea what they own – no proper data package, appendix, or supplemental info by which to assess the drug’s claims.",
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      "text": "The best we can locate is a 2023 conference presentation by Miller on Soleno’s publications page, with a large disclaimer on page 3 – “analyses in this presentation are preliminary and may be subject to change.”",
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      "text": "analyses in this presentation are preliminary and may be subject to change. — Soleno Therapeutics (from conference presentation disclaimer)",
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      "text": "Source: https://investors.soleno.life/static-files/dae000f3-5c9a-450f-be0a-1b6c32d13fed",
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