{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 408, "pageCount": 415, "prevPage": 407, "nextPage": 409, "slideType": "testimonial", "function": "diagnose_problem", "density": "dense", "nDataPoints": 0, "notes": "The slide uses direct quotes from an endocrinologist to frame potential medical risks as a barrier to adoption.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/408", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-408", "components": [ { "bbox": null, "kind": "callout", "text": "By definition, many of these patients are going to be susceptible to full-blown diabetes and impaired glucose tolerance.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2b7-f54f4c72db06", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.05, "w": 0.86, "x": 0.07, "y": 0.34 }, "kind": "paragraph", "text": "Concerned about diabetes risk; “don't think it's a miracle drug”; enthusiasm limited to “giving it a shot” in some patients where nothing has worked", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "10bb0c55-14d3-4298-af3c-5f26d27fbe60", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.22, "w": 0.86, "x": 0.07, "y": 0.59 }, "kind": "paragraph", "text": "Concerned about hirsutism; fluid retention and cardiac risk; diabetes\nQ: “Which side effects are you concerned about?”\nA: “The hirsutism that they keep, they talk about the hirsutism; that always is an issue. And the fluid retention. But again, in theory, my feeling is if they don't have underlying cardiovascular disease and maybe diuretics, they may solve that particular problem. And the potential for hyperglycemia. And again, because many of these patients are diabetics to begin with, that is something that there is some concern for that as well.” - Endocrinologist based in NYC, 15 PWS patients", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "c9a779eb-94a8-4b4f-b830-349d0870a3bd", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.86, "x": 0.07, "y": 0.41 }, "kind": "quote", "text": "“By definition, many of these patients are going to be susceptible to full-blown diabetes and impaired glucose tolerance. I have one patient who I saw last week. She's a 28-year-old who's living at home, who weighs about 340 pounds with Prader-Willi. She actually is on a GLP-1 and she's on insulin. I have run a GLP-1 and I've had some success. But she has diabetes. And you're concerning me even more in terms of the information you're giving me from the primary investigators. Obviously, I don't think it's a miracle drug, but I have some patients where I exhausted everything else. And I felt that it's something that I need to at least give it a shot and see what happens.” - Endocrinologist based in NYC, 15 PWS patients", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "1ece5204-5c3a-4e50-9a8e-df10423bd823", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "By definition, many of these patients are going to be susceptible to full-blown diabetes and impaired glucose tolerance. I have one patient who I saw last week. She's a 28-year-old who's living at home, who weighs about 340 pounds with Prader-Willi. She actually is on a GLP-1 and she's on insulin. I have run a GLP-1 and I've had some success. But she has diabetes. And you're concerning me even more in terms of the information you're giving me from the primary investigators. Obviously, I don't think it's a miracle drug, but I have some patients where I exhausted everything else. And I felt that it's something that I need to at least give it a shot and see what happens. — Endocrinologist based in NYC, 15 PWS patients", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2b7-f801dc6ebfd7", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.25, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "1326513f-352f-4991-b07c-efd99c4a15e0", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.22, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "The endocrinologist indicated significant concern about diabetes, edema, and cardiac issues if they have pre-existing factors: “by definition, many of these patients are going to be susceptible to full-blown diabetes and impaired glucose tolerance... obviously, I don't think it's a miracle drug... hirsutism, that always is an issue...the potential for hyperglycemia..and again, because many of these patients are diabetics to begin with, that is something that there is some concern for that as well...”", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "cbe9f35e-3cfe-4f84-86a9-4bc221c83744", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }