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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "notes": "The slide highlights a contradiction between the drug's intended use and its physiological impact on a vulnerable patient population.",
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      "text": "This seems to be very, very logical with this medication. But you're exactly right. This is a generally obese patient population, and if they don't have diabetes already, they're certainly at high risk to become diabetic. They have a limited life expectancy to begin with. But they are, as a general rule, at least high risk to develop diabetes with a drug that's known to cause your blood sugars to go up...Yeah, it's a real risk with this group... your child is already at high risk to become diabetic. It's probably only going to go up with this medication. That probably means that eventually you're going to be on diabetes medicines and the like.",
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      "text": "Diabates is “real risk with this group” given Vykat mechanism of action + PWS patients predisposition to diabetes; risk “probably only going to go up with this medication”",
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      "text": "Q: “I think 30% to 40% of PWS patients are diabetic. The mechanism of action here is the KATP channel. It suppresses insulin, so it raises blood sugar. What is your assessment of the diabetes risk here? The mechanism of action is, essentially inducing hyperglycemia.” A: “No, you're exactly right...the experience that I have with diazoxide has been for the treatment of hypoglycemia...it only makes sense. This seems to be very, very logical with this medication. But you're exactly right. This is a generally obese patient population, and if they don't have diabetes already, they're certainly at high risk to become diabetic. They have a limited life expectancy to begin with. But they are, as a general rule, at least high risk to develop diabetes with a drug that's known to cause your blood sugars to go up...Yeah, it's a real risk with this group... your child is already at high risk to become diabetic. It's probably only going to go up with this medication. I know it seems a little counterintuitive that if we're fighting less about food, that maybe their blood sugars should get better, but that doesn't really appear to be the case. That probably means that eventually you're going to be on diabetes medicines and the like.” - Endocrinologist in TX, private practice with 5 PWS patients",
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      "text": "“This seems to be very, very logical with this medication. But you're exactly right. This is a generally obese patient population, and if they don't have diabetes already, they're certainly at high risk to become diabetic. They have a limited life expectancy to begin with. But they are, as a general rule, at least high risk to develop diabetes with a drug that's known to cause your blood sugars to go up...Yeah, it's a real risk with this group... your child is already at high risk to become diabetic. It's probably only going to go up with this medication. That probably means that eventually you're going to be on diabetes medicines and the like.” — Endocrinologist in TX, private practice with 5 PWS patients",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "The endocrinologist stated that it is “very, very logical” that Vykat would amplify diabetes risk in already vulnerable PWW patients, given its mechanism of action: “high risk to develop diabetes with a drug that's known to cause your blood sugars to go up...yeah, it's a real risk with this group... your child is already at high risk to become diabetic...it's probably only going to go up with this medication...that probably means that eventually you're going to be on diabetes medicines...”",
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