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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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      "text": "Most private practice endocrinologists may have zero to two PWS patients at most",
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      "text": "“I’m better read than average”: no start forms submitted, families are disinterested/hesitant; clinical data is “underwhelming” with a history of failed trials and no hard endpoint; “old news” as endocrinologists are very familiar with diazoxide and don’t view it as novel, and would just use generic suspension instead anyway; thinks “severity of edema and cardiac risk is probably being underplayed” and is “real and significant”; worries about diabetes risk; is unwilling to invest administrative time to push for insurance approval as “I don’t believe it is that powerful or effective to begin with” and “not worth it to fight super hard” – “I don’t have anybody who’s actually started it...one of my patients...we’ve had a discussion...but the family wanted to...think about it first...some of them are going to be intrigued with any new options, and others are going to be a little more hesitant.”",
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      "text": "Private practice with 5 PWS patients; no start forms submitted; one family wants to “learn about” and “think about it” A: “I am in private practice at a medium-sized private practice. We have about four docs now. I do a bit of everything within endocrinology.” Q: “And how many PWS patients do you currently manage?” A: “Maybe five. I have my little cohort of those patients, but this is not a common enough condition that I have a large group.” Q: “Have you submitted any start forms for Vykat or do you have any patients on it?” A: “So far, I don’t have anybody who’s actually started it. I have one of my Prader-Willi patients, who I saw just recently, and we’ve had a discussion about getting on the medication. But the family wanted to read about it, learn about it, think about it a little bit first. And so, some of them are going to be intrigued with any new option, and others are going to be a little more hesitant for something that was just recently approved, don’t necessarily feel ready to start a brand new medication or anything along those lines.” - Endocrinologist in TX, private practice with 5 PWS patients",
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      "text": "Most private practice endocrinologists may have zero to two PWS patients at most “I do think I’m probably better read than average. I would guess that a lot of my private practice colleagues have between zero and two Prader-Willi patients. Basically, don’t see it or have like one or two people. I have a little bit more than average. And it just happens to be in my little area, the pedi-endo that’s the busiest pedi-endo is actually really quite good about making sure that they actually come to see us. And, as a result, we’ve gotten a bit more of these patients.” - Endocrinologist in TX, private practice with 5 PWS patients",
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      "text": "So far, I don't have anybody who's actually started it. I have one of my Prader-Willi patients, who I saw just recently, and we've had a discussion about getting on the medication. But the family wanted to read about it, learn about it, think about it a little bit first. And so, some of them are going to be intrigued with any new option, and others are going to be a little more hesitant for something that was just recently approved, don't necessarily feel ready to start a brand new medication or anything along those lines. — Endocrinologist in TX, private practice with 5 PWS patients",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "PWS endocrinologist #9: In private practice in a major Texas metropolitan area with 4 endocrinologists and sees 5 PWS patients personally - and is extremely skeptical of Vykat",
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