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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "notes": "The slide uses expert interview transcripts to undermine the value proposition of the drug Vykat.",
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      "text": "Strongly prefers liquid formulation over tablet",
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      "text": "Skeptical of Vykat and compared it to Aduhelm debacle – little benefit for tremendous risk; appeared skeptical given generic diazoxide suspension is a substitute – \"more questions than answers\"",
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      "text": "Q: \"If somebody stands up at a conference, some KOL gives a talk and says, here's oral suspension, here's the equivalent — even the people that love this drug, why would they not use oral suspension? What am I missing here?\"\nA: \"I don't think you're wrong in that. I think there are probably more questions than answers. I do pharma work. I've been a PI and I've been a medical monitor for growth hormone stuff and puberty stuff, and I've been on DSMBs and actually even went to a pre-NDA meeting once, and I was in the bullpen for the outside board review once. I think a perfect example is the Alzheimer's drug. Alzheimer's is a horrible, fatal, expensive disease with no treatment. And so, if you're willing to take the risk of CNS bleeding on the chance that we may stabilize a decline and give mom, dad, grandma, and grandpa a year or three years of an interactive life, yeah. And there are other drugs that are being looked at. If we're looking for a magic bullet, this isn't magic, and it's not a targeted bullet.\" - Pediatric endocrinologist, division chief at an academic center",
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      "text": "Q: \"If somebody gave you a table, all things being equal, which one would you prefer - an oral suspension or this DCCR extended-release tablet?\"\nA: \"Of course, we would want to use an oral suspension. Some medications we don't have. We don't have thyroid hormone suspension; we don't have hydrocortisone oral suspension. So, we had it made locally, or we crush tablets and give it in formula. But yeah, we're pediatricians — liquids rock....\" - Pediatric endocrinologist, division chief at an academic center",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "The endocrinologist compared Vykat to the Aduhelm debacle as taking on a tremendous risk for dubious benefit, and concurred when we asked why anyone would prescribe the drug vs. generic diazoxide, stating that an oral suspension is obviously superior in pediatrics vs. tablets",
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