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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "notes": "The slide uses highlighted text to emphasize key concerns about Vykat's safety profile and Miller's private skepticism.",
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      "text": "Having that part of the discussion with her, she wasn't sanguine, but I think she was realistic, and said, this may help; it's not for everybody... I think she's aggressive and a little out there in regards to therapies.",
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      "text": "Highly concerned about diabetes risk from prior experience using diazoxide for hyperinsulinism; under the impression that Jennifer Miller discontinued a patient on Vykat b/c they developed diabetes; was surprised at drug discontinuation",
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      "text": "Under the impression that Jennifer Miller wasn’t as optimistic or promotional about Vykat in private",
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      "text": "A: “And people do come to her from other parts of the country to see her — patients with means. We had a family diagnosed as an infant. And they went down to see her once, and I ran into her here and talked to her. I said, by the way, are you still seeing this kid? Because I haven’t seen them back. And again, I don’t have an ego, I could care less if patients go elsewhere...I think the thing that she told me most interestingly — because I was nonplussed by the change in BMI — but she said, anecdotally, that the behavior completely changes. And what she did tell me, and again, this is an n of one, is that she had a patient who was developing diabetes, and I don’t remember the specifics, but she was going to stop the medication — and again, I don’t remember the specifics, that’s the weird thing — because she thought that with other interventions that she had an armamentarium, maybe GLPs — that they can get rid of the diabetes.”\nQ: “This patient developed diabetes because of Vykat?”\nA: “Yeah. And again, my concern having treated plenty of kids with diazoxide for hyperinsulinism is what’s the glycemic issues that are going on? And again, like I said, this n of one was very interesting, that Jennifer Miller said, hey, treat the diabetes...”\nQ: “Do you know how old was that patient that developed diabetes?”\nA: “She was a teenager.” - Pediatric endocrinologist, division chief at an academic center",
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      "text": "“Having that part of the discussion with her, she wasn’t sanguine, but I think she was realistic, and said, this may help; it’s not for everybody... I haven’t heard anything about her, other than she’s aggressive and a little out there in regards to therapies.” - Pediatric endocrinologist, division chief at an academic center",
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      "text": "“Having that part of the discussion with her, she wasn't sanguine, but I think she was realistic, and said, this may help; it's not for everybody... I think she's aggressive and a little out there in regards to therapies.” — Pediatric endocrinologist, division chief at an academic center",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "The endocrinologist was troubled by a recent conversation with Jennifer Miller regarding diabetes risk, opining that she wasn’t optimistic about Vykat – “she wasn’t sanguine”; “she’s aggressive and a little out there in regards to therapies” – and believed that she took a teenage patient off the drug after developing diabetes, calling the anecdote “weird” – “what she did tell me...is that she had a patient who was developing diabetes...she was going to stop the medication...that’s the weird thing...because she thought that with other interventions that she had an armamentarium...that they can get rid of the diabetes... my concern having treated plenty of kids with diazoxide for hyperinsulinism is what’s the glycemic issues that are going on?...again...this n of one was very interesting, that Jennifer Miller said, hey, treat the diabetes...”",
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