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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "sourceTypeLabel": "Short seller",
  "presentationDate": "2025-08-15 00:00:00",
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      "text": "And I posed that question to this doctor. I said, \"Why wouldn't I just prescribe diazoxide?\" And she said, Oh, it doesn't work.' But I don't know if that was because she was also motivated to get the Vykat approved.",
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      "text": "Other endocrinologists are asking the same questions about generic substitutability; company rep \"didn't have an answer\"; answer was unconvincing; \"just a little bit of lip service\"",
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      "text": "Jennifer Miller allegedly told endocrinologist that generic diazoxide doesn't work; skeptical of her motivations\n\"And I posed that question to this doctor. I said, \"Why wouldn't I just prescribe diazoxide?\" And she said, Oh, it doesn't work.' But I don't know if that was because she was also motivated to get the Vykat approved.\" - Pediatric endocrinologist, leads one of the largest PWS clinics in US with 30-40 patients; 11 endocrinologists, major academic center",
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      "text": "Q: \"This whole thing just seems like in one of these meetings, an annual society meeting, it's going to take one journal paper where somebody gets up there and says, here are the equivalent dosages of oral suspension versus tablet. And my read is that the company is going to be in trouble because it's a very small world, and you can't be the only one asking this question.\"\nA: \"No, I don't think I am. As a prescriber, it's always nice to have an FDA indication for a medication that has side effects, because if I'm just going off-label with a drug that could give them diabetes or edema or death, then I feel like I have more cover prescribing a medication with an FDA indication. But I don't think anything you're saying is surprising to me, or that all the things that I've been thinking to myself, and so, I don't disagree.\"\nQ: \"Have you asked the company about this issue?\"\nA: \"I feel like I've asked representatives, and I don't think the answer can really convince me that I had my question resolved.\"\nQ: \"And you asked a rep, or you asked some trial investigators, or spokespeople?\"\nA: \"I think a rep.\"\nQ: \"And do you remember what the rep said? I'm just curious how they're trying to position it.\"\nA: \"The rep said that he didn't have the answer but that he knows that doctors participating in making it believe that the diazoxide doesn't work. Maybe the answer had to do with something, obviously, to the extended-release nature of the drug. But it wasn't a complete enough answer that it really made me convinced that it wasn't just a little bit of lip service.\" - Pediatric endocrinologist, leads one of the largest PWS clinics in US with 30-40 patients; 11 endocrinologists, major academic center",
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      "text": "No, I don't think I am. As a prescriber, it's always nice to have an FDA indication for a medication that has side effects, because if I'm just going off-label with a drug that could give them diabetes or edema or death, then I feel like I have more cover prescribing a medication with an FDA indication. But I don't think anything you're saying is surprising to me, or that all the things that I've been thinking to myself, and so, I don't disagree. — Pediatric endocrinologist",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "The endocrinologist stated that other physicians are asking the same question about generic substitution; that’s he’s asked Soleno why Vykat is necessary versus the generic and that the answer lacked credibility; and that he also asked Jennifer Miller who allegedly stated that regular diazoxide doesn’t work – an answer he viewed as similarly questionable, and which we view as brazenly disingenuous marketing on behalf of Soleno given the lack of any clinical evidence to support it.",
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