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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses direct quotes to expose the contradiction between the physician's knowledge of drug inefficacy and their continued prescription behavior.",
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      "text": "Endocrinologist feels “hypocritical” for prescribing the drug given his reservations; willing to prescribe to desperate families pushing for it, but no interest in appealing insurer denials given lack of efficacy",
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      "text": "Clinical data is “marginal”; aware of clinical trial failure; just prescribing to take a flyer because of “pressure and expectation from families”",
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      "text": "Endocrinologist feels “hypocritical” for prescribing the drug given his reservations; willing to prescribe to desperate families pushing for it, but no interest in appealing insurer denials given lack of efficacy",
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      "text": "“You've identified a lot of the issues that I've been thinking about. And yet, I'm still trying to get people on it. I guess that I'm feeling maybe a little more hypocritical after talking to you, but I feel like the expectation is there that since this is FDA approved and available, that trying to get on the drug is important to families. What I'm not doing is I'm not feeling like when I get a denial that the patient is being robbed of something that's life-saving, and that I want to devote all my energy to getting this approved because it's a travesty if they're getting denied, which would be the case if I was prescribing the drug that I actually felt like was going to be life-saving to a patient that was getting denied.” - Pediatric endocrinologist, leads one of the largest PWS clinics in US with 30-40 patients; 11 endocrinologists, major academic center",
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      "text": "“I'm hoping that there's some benefit from the drug. And that some of the issues that you're describing with the studies — I wasn't aware of all of them, but of course, the failure of the clinical trial and then the extension that had the signal, of course, I'm familiar with that. I agree that it's marginal. Of course, I'm hoping that they're going to be offered the medication now that it's available...” - Pediatric endocrinologist, leads one of the largest PWS clinics in US with 30-40 patients; 11 endocrinologists, major academic center",
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      "text": "“the failure of the clinical trial and then the extension that had the signal, of course, I'm familiar with that...I agree that it's marginal...there is definitely some pressure and expectation from families” — Pediatric endocrinologist, leads one of the largest PWS clinics in US with 30-40 patients; 11 endocrinologists, major academic center",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "The endocrinologist noted the failure of the phase 3 trial and the weak data from the subsequent withdrawal study that pushed it over the line to FDA approval; confessed to what we interpret as guilt and “hypocrisy” at still prescribing the drug to desperate families; and stated that he didn’t care enough to fight insurance denials",
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