{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 364, "pageCount": 415, "prevPage": 363, "nextPage": 365, "slideType": "expose_contradiction", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide uses verbatim quotes from a consultation call to highlight a discrepancy between the company's risk management (handouts) and the physician's expectations of transient vs. permanent side effects.", "elementsJson": [ "paragraph", "quote_block" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/364", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-364", "components": [ { "bbox": { "h": 0.2, "w": 0.86, "x": 0.07, "y": 0.51 }, "kind": "callout", "text": "“Serious cardiac events” and “pulmonary edema”; skeptical/concerned about Soleno rep’s answer to questions about pulmonary edema; “permanent edema”; handout to recognize edema\n“We do get Echos in all babies. “Usually, we get a before echo, and then we'll typically get one a couple of weeks later. If that's okay, we don't do them every two weeks or consistently unless we're always talking about changes in respiration or things like that. As far as serious cardiac events, we did talk about pulmonary edema at the visit, and she even said something about giving people a handout and how to recognize edema. And I was just like, \"huh!\" I would expect something transient, but I wouldn't expect a permanent edema, to be honest...” - Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients", "attrs": null, "subkind": "primary", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "397ca2b1-e7ec-4d9c-8552-fc4898c2fd08", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "callout", "text": "Soleno's handout suggests significant concern about edema", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2b4-eaf86a7bbdf4", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.86, "x": 0.07, "y": 0.73 }, "kind": "list", "text": "Soleno’s handout suggests significant concern about edema\nQ: “Is that what the rep hinted at? They were worried enough about edema that they gave a handout?”\nA: “Yes. They said something about the families are very good and teaching people how to recognize the edema at home, which, I'm an endocrinologist, and I can certainly do that, pitting versus not. But that's not something we're typically do.” - Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "bbcd4df3-c592-4268-bc60-2ee49c95a1e5", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.22 }, "kind": "paragraph", "text": "“As far as serious cardiac events, we did talk about pulmonary edema at the visit, and she even said something about giving people a handout and how to recognize edema...and I was just like, \"huh!\" I would expect something transient, but I wouldn't expect a permanent edema, to be honest....” When we asked if Soleno was worried enough about edema to actually give families a handout, the physician replied “yes...they said something about the families are very good and teaching people how to recognize the edema at home, which, I'm an endocrinologist, and I can certainly do that, pitting versus not...but that's not something we're typically do.”", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "9f13e20d-915e-4f3e-b9dd-7ec9a2ee2a8a", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“As far as serious cardiac events, we did talk about pulmonary edema at the visit, and she even said something about giving people a handout and how to recognize edema. And I was just like, \"huh!\" I would expect something transient, but I wouldn't expect a permanent edema, to be honest....” — Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2b4-ecd4ea47f1f5", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.25, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "7c07feb8-95cc-4321-91ec-61eed48d676b", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Endocrinologist #4 was surprised at comments by the Soleno rep which he interpreted as meaning that “permanent edema” is a side effect of the drug, versus something transient", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "7699787b-76b1-4867-90c4-9378185b28ca", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }