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      "text": "Soleno appears to be worried about permanent edema, as their rep suggested patients remaining on diuretics as \"standard of care\" with Vykat; physicians \"surprised\" at the answer; edema is a \"known side effect\" of diazoxide",
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      "text": "Soleno appears to be worried about permanent edema, as their rep suggested patients remaining on diuretics as \"standard of care\" with Vykat; physicians \"surprised\" at the answer; edema is a \"known side effect\" of diazoxide",
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      "text": "\"Every baby less than a year old, we put on diuretics, so it's a known side effect. When they get older, we actually stop it. Most of the time they don't still need it, which I was a little bit surprised that they were talking about treating kids with diuretics as a standard of care with this medication — that was one of the things that the rep said. I was surprised about that because if I have somebody with congenital hyperinsulinism that has a mutation that responds to diazoxide, and we continue to treat them, and there's a couple later on in life, I would not treat that kid with a diuretic. Usually, they're old enough and they do fine. And maybe it's because it's twice a day and it's not extended-release.\" - Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients",
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      "text": "Every baby less than a year old, we put on diuretics, so it's a known side effect. When they get older, we actually stop it. Most of the time they don't still need it, which I was a little bit surprised that they were talking about treating kids with diuretics as a standard of care with this medication — that was one of the things that the rep said. I was surprised about that because if I have somebody with congenital hyperinsulinism that has a mutation that responds to diazoxide, and we continue to treat them, and there's a couple later on in life, I would not treat that kid with a diuretic. Usually, they're old enough and they do fine. And maybe it's because it's twice a day and it's not extended-release. — Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Endocrinologist #4 indicated fear of Vykat-induced edema and serious cardiac events, and was skeptical of the Vykat rep’s answers which suggested that Soleno views edema as a feature of the drug.",
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