{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 361, "pageCount": 415, "prevPage": 360, "nextPage": 362, "slideType": "testimonial", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide uses direct quotes from a pediatric endocrinologist to undermine the viability of a drug (Vykat/diazoxide).", "elementsJson": [ "paragraph", "quote_block" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/361", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-361", "components": [ { "bbox": null, "kind": "callout", "text": "I can't say there's great enthusiasm. And then the price tag.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2b5-1625f61fa93e", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.86, "x": 0.07, "y": 0.65 }, "kind": "paragraph", "text": "Highly concerned about diabetes risk given longstanding familiarity with diazoxide among endocrinologists\n“I think the thing that probably worries me the most is just the hyperglycemia, and what to do with that. You already have an obese population that's at risk for type 2 diabetes.” - Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "240f90d5-bd97-4f88-84db-a8d553c5f9ee", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.38 }, "kind": "paragraph", "text": "CHOP is the “Mecca” for diazoxide treatment for hyperinsulinism; hair growth is extremely bothersome to patients – “hairy baby”; concerned with adverse effects like edema, pulmonary hypertension; “can't say there's great enthusiasm” for Vykat; “I think all of us, so particularly a lot of us who trained, there's four of us that trained to CHOP and diazoxide. We have edema, pulmonary hypertension, even the hair, to be honest. I can't tell you how many kids — for the hyperinsulinism CHOP is the Mecca. I can't tell you how many parents, just the hair is so bothersome. The alternative is your child might need to have your pancreas removed, but just the cosmetic. Maybe it'll be different in older people that already have hair and it's not a hairy baby. But I can't say there's great enthusiasm. And then the price tag. I think we're all going to say, okay, this is nice, but I think you're probably going to have some patients that respond, and maybe it's worth it or not. If you're having to lock the cabinets and things.” - Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "d26cdfd8-8971-4665-9e73-11ed2425619a", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "We have edema, pulmonary hypertension, even the hair, to be honest. I can't tell you how many kids — for the hyperinsulinism CHOP is the Mecca. I can't tell you how many parents, just the hair is so bothersome. The alternative is your child might need to have your pancreas removed, but just the cosmetic. Maybe it'll be different in older people that already have hair and it's not a hairy baby. But I can't say there's great enthusiasm. And then the price tag. I think we're all going to say, okay, this is nice, but I think you're probably going to have some patients that respond, and maybe it's worth it or not. If you're having to lock the cabinets and things. — Pediatric endocrinologist at a Delaware academic center with eight endocrinologists and ~50 PWS patients", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2b5-1b03523722ed", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.25, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "6b74fda9-707d-4147-b178-a5b5e9461b7d", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Endocrinologist #4 indicated he and his colleagues have extensive experience with diazoxide in another indication and are highly concerned about diabetes risk among other side effects: “we have edema, pulmonary hypertension, even the hair, to be honest...for the hyperinsulinism CHOP is the Mecca. I can't tell you how many parents, just the hair is so bothersome...I can't say there's great enthusiasm...and then the price tag”; “the thing that probably worries me the most is just the hyperglycemia...you already have an obese population that's at risk for type 2 diabetes.”", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e421cdbc-caf6-41d0-b3bf-be3c5a4da85f", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }