{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 350, "pageCount": 415, "prevPage": 349, "nextPage": 351, "slideType": "quote_slide", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide presents a Q&A format highlighting expert skepticism regarding the drug's safety profile and market relevance.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/350", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-350", "components": [ { "bbox": null, "kind": "callout", "text": "Endocrinologist #2 expressed surprise that diazoxide was even approved with a Prader-Willi indication, particularly given its mechanism of action is to basically raise blood sugar and induce hyperglycemia in a population already prone to diabetes", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2b4-2fb8b55bb3e9", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.06, "w": 0.86, "x": 0.07, "y": 0.57 }, "kind": "paragraph", "text": "Diabetes risk is \"very concerning\"; surprised this mechanism of action would be used in PWS patients; \"we'll see\" attitude at large internal discussion about Vykat; \"no one talked about\" Vykat at the recent annual conference", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "63028600-3c5e-4836-9cc7-a4e99bd5efc7", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.64 }, "kind": "quote", "text": "Q: \"When I looked at the pilot study, the Phase 2 with 13 patients, one got full-blown diabetes, others became pre-diabetic. Now, this is completely inherent to the mechanism of action, because it's suppressing insulin production. So, the fact that this would happen in a patient population where 30% or 40% are already diabetic, it seems nuts.\"\nA: \"That is very concerning. We use this drug to make blood sugars go up in our population...well, we've talked about theoretically, the hypoglycemic effect, because we use this drug all the time, we're the biggest referral center for hyperinsulinism in little babies. And we also talked about it being a little surprising because we weren't expecting this to be the type of drug that would be used in this condition. But the study we had reviewed, it was a short article — I really don't remember the details. People seem to say, okay, we'll see. And then their presence in it, certainly at the meeting, I didn't go to any specific talks about this, but no one talked about it. I don't think it was a big enough topic to make the headlines.\" – Pediatric oncologist, Children's Hospital of Philadelphia (CHOP), top center for pediatric endocrinology and diazoxide use in hyperinsulinism", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "ef67f5b2-644f-429c-95e3-cfc5f27ec5c7", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "That is very concerning. We use this drug to make blood sugars go up...we've talked about theoretically, the hypoglycemic effect, because we use this drug all the time, we're the biggest referral center for hyperinsulinism in little babies...we also talked about it being a little surprising because we weren't expecting this to be the type of drug that would be used in this condition...people seem to say, okay, we'll see...certainly at the meeting, I didn't go to any specific talks about this, but no one talked about it. I don't think it was a big enough topic to make the headlines. — Pediatric oncologist, Children's Hospital of Philadelphia (CHOP)", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2b4-32092099fa50", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.25, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "276f7fd4-cd63-40f7-8e2f-1818117c6056", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.45, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Endocrinologist #2 expressed surprise that diazoxide was even approved with a Prader-Willi indication, particularly given its mechanism of action is to basically raise blood sugar and induce hyperglycemia in a population already prone to diabetes; and stated Vykat wasn't even a topic at the recent annual pediatric endocrinology conference - \"That is very concerning. We use this drug to make blood sugars go up...we've talked about theoretically, the hypoglycemic effect, because we use this drug all the time, we're the biggest referral center for hyperinsulinism in little babies...we also talked about it being a little surprising because we weren't expecting this to be the type of drug that would be used in this condition...people seem to say, okay, we'll see...certainly at the meeting, I didn't go to any specific talks about this, but no one talked about it. I don't think it was a big enough topic to make the headlines.\"", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "0811bd30-e4f9-4517-862f-b285f4af6e17", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }