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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "notes": "The slide uses expert quotes to undermine the company's claims regarding the drug's safety profile and market potential.",
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      "text": "“The downside, of course, is hyperglycemia and maybe some of the peripheral edema, fluid retention, maybe exacerbating some heart failure.” – Endocrinologist with academic and community hospital affiliations",
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      "text": "“I think the one thing to keep in mind is how prevalent diabetes is in this patient population. I would say somewhere in the range of probably 40% of my patients with Prader-Willi, even at this young age, already have diabetes. And I’ll be especially leery about introducing diazoxide into a diabetic patient for all sorts of obvious reasons. So, that is an important limitation on the overall kind of access to an already rare disease.” -Endocrinologist; academic and community hospital affiliations.",
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      "text": "“In this patient population, especially, it doesn’t take much to make them diabetic or certainly hyperglycemic…and no surprise, given this mechanism of action. No surprise…and importantly, some patients get ketoacidotic because the insulin suppression is so potent at these doses that you essentially render the patient to be type-one diabetic, which increases the risk of ketoacidosis, which could be potentially lethal in wide use being in this context.” Endocrinologist; academic and community hospital affiliations.",
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      "text": "The downside, of course, is hyperglycemia and maybe some of the peripheral edema, fluid retention, maybe exacerbating some heart failure.",
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      "text": "Diabetes and edema “exacerbating” heart failure are risks",
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      "text": "Concerned about diabetes risk from mechanism of action and “lethal” ketoacidosis in particular",
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      "text": "High prevalence of and concern regarding diabetes limits TAM for Vykat",
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      "text": "In this patient population, especially, it doesn't take much to make them diabetic or certainly hyperglycemic...and no surprise, given this mechanism of action. No surprise...and importantly, some patients get ketoacidotic because the insulin suppression is so potent at these doses that you essentially render the patient to be type-one diabetic, which increases the risk of ketoacidosis, which could be potentially lethal in wide use being in this context. — Endocrinologist; academic and community hospital affiliations",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Endocrinologist #1: Concerned about inducing diabetes and heart failure from edema and thinks it’s inherent to diazoxide’s mechanism of action; potentially fatal side effects from DKA; prevalence of diabetes in PWS patients shrinks the TAM",
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