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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "Moreover, this investigator comments cast grave doubt on the validity of the withdrawal study, which showed an abrupt spike in HQ-CT scores in the placebo group for such a “slow drug.”",
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      "text": "“All” or “most” patients develop hypertrichosis",
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      "text": "Investigator claims the drug takes about 3 months or longer to work",
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      "text": "The investigator confirmed that “most” or “all” patients developed hypertrichosis (hairiness), thereby unblinding the trial – “the patients that I saw, most of them developed some degree of hypertrichosis.” In addition, the investigator stated “drug takes a long time to work” – “in the first three months...there isn’t a change...probably more towards 12 weeks...plateaus at about 35, 40 weeks...it’s a slow drug.” We note that the phase 3 trial was only 13 weeks, and that other investigators found it odd and troubling that the purported hyperphagia improvements occurred far into the trial during the open-label phase. Moreover, this investigator comments cast grave doubt on the validity of the withdrawal study, which showed an abrupt spike in HQ-CT scores in the placebo group for such a “slow drug.”",
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      "text": "“The drug takes a long time to work. So, sometimes people think, initially, in the first three months, that there isn’t a change, but then you will see their behavior change or their weight go up, either one.” Q: “How long do you think it takes to work, to kick in?” A: “I think it takes about 8 to 12 weeks to work, probably more towards 12 weeks. And that’s also what you see when you look at data. At 12 weeks, you start to see a significant difference between placebo and the drug. Then the effect is more clear by 16 weeks, and it only plateaus at about 35, 40 weeks. It’s a slow drug.” -Trial investigator/author, pediatric endocrinologist",
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      "text": "“I think that the hypertrichosis, clearly, it’s hypertrichosis. And over time, all the patients have developed hypertrichosis...the patients that I saw, most of them developed some degree of hypertrichosis. Yes.” -Trial investigator/author, pediatric endocrinologist",
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      "text": "“The drug takes a long time to work. So, sometimes people think, in the first three months, that there isn't a change, but then you will see their behavior change or their weight go up, either one.”; “I think it takes about 8 to 12 weeks to work, probably more towards 12 weeks. And that's also what you see when you look at data. At 12 weeks, you start to see a significant difference between placebo and the drug. Then the effect is more clear by 16 weeks, and it only plateaus at about 35, 40 weeks. It's a slow drug.”; “I think that the hypertrichosis, clearly, it's hypertrichosis. And over time, all the patients have developed hypertrichosis...the patients that I saw, most of them developed some degree of hypertrichosis. Yes.” — Trial investigator/author, pediatric endocrinologist",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #8 inadvertently highlighted two red flags about the trials, while continuing to defend the drug despite an almost 100% discontinuation rate at the site.",
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