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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "notes": "The slide uses direct quotes from a trial investigator to undermine the value proposition of the drug Vykat.",
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      "text": "The cost is absolutely outrageous...my concern is certainly, is this cost-effective? And if they are charging half a million to $1 million per person, that is very expensive for a drug that isn’t that novel ...it’s hard to justify the cost of the diazoxide, the normal formulation, which the Proglycem is about $800 a bottle.",
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      "text": "Not worth the “absolutely outrageous” cost for Vykat versus cheap liquid diazoxide – “a drug that isn’t that novel”\n“The cost is absolutely outrageous…my concern is certainly, is this cost-effective? And if they are charging half a million to $1 million per person, that is very expensive for a drug that isn’t that novel …it’s hard to justify the cost of the diazoxide, the normal formulation, which the Proglycem is about $800 a bottle.” -Trial investigator, endocrinologist, key opinion leader for PWS",
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      "text": "Prefer liquid formulation if PK is identical; easier to titrate; already uses generic diazoxide capsules in older kids\nQ: “if you had to pick one formulation, which one do you think checks off more boxes if they’re pharmaceutically identical?”\nA: “If it’s identical, then I would probably pick the liquid preparation because I can titrate it better and offer it to more patients. Going back to hyperinsulinism, most of my patients who are on diazoxide take the liquid preparation. There’s only a couple of patients who take the capsules, so the older ones take the capsules, but the majority —.” -Trial investigator, endocrinologist, key opinion leader for PWS",
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      "text": "“The cost is absolutely outrageous...my concern is certainly, is this cost-effective? And if they are charging half a million to $1 million per person, that is very expensive for a drug that isn’t that novel ...it’s hard to justify the cost of the diazoxide, the normal formulation, which the Proglycem is about $800 a bottle.” — Trial investigator, endocrinologist, key opinion leader for PWS",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #7 slammed Vykat’s cost versus generic diazoxide or its inexpensive Proglycem version – “absolutely outrageous…my concern is certainly, is this cost-effective…very expensive for a drug that isn’t that novel…it’s hard to justify the cost…Proglycem is about $800 a bottle.” He stated that he prefers a liquid formulation over a tablet like Vykat – “I can titrate it better and offer it to more patients…most of my patients who are on diazoxide take the liquid…only a couple of patients who take the capsules.”",
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