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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses a Q&A transcript format to expose flaws in the clinical trial design regarding pill size.",
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      "text": "In order to get in the study, you had to be able to demonstrate that you could swallow a pill...I don't know what to tell you.",
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      "text": "Tablet was too large for some enrollees; had to use smaller tablet; excluded kids who couldn't swallow the pill",
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      "text": "Q: “What did you observe with the tablet, the DCCR? How large is the tablet, first of all? This other investigator called it a horse pill. Is it large?”\nA: “Well, the 150 milligram one was big. And so there were some folks who couldn’t swallow that big a pill, so we had to use the 75 mg for them instead. So, yeah, the 150 mg is a big pill.”\nQ: “Like, how big is it?”\nA: “It’s for sure bigger than an Advil. Twice the size of Advil?”\nQ: “When I asked this other investigator about it, he said, well, what I observed, the patients are just chewing it, which undermines the entire extended release.”\nA: “Oh no, they can’t —”\nQ: “They’re not supposed to, but what are you going to do? It’s a kid”\nA: “Well, no. In order to get in the study, you had to be able to demonstrate that you could swallow a pill. I don’t know what to tell you.” -Trial investigator, pediatrician/geneticist, professor",
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      "text": "Trial investigator #5 stated that the Vykat tablet was too large for some trial patients and that they had to use several of the smaller dose tablets instead. When we asked why anyone would even use a tablet formulation for children, the investigator replied that “in order to get in the study, you had to be able to demonstrate that you could swallow a pill…I don’t know what to tell you” – “some folks couldn’t swallow that big a pill, so we had to use the 75 mg for them instead…so yeah, the 150 mg is a big pill.”",
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      "text": "“Well, the 150 milligram one was big. And so there were some folks who couldn't swallow that big a pill, so we had to use the 75 mg for them instead. So, yeah, the 150 mg is a big pill.” — Trial investigator, pediatrician/geneticist, professor",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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