{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 319, "pageCount": 415, "prevPage": 318, "nextPage": 320, "slideType": "expose_contradiction", "function": "expose_contradiction", "density": "overcrowded", "nDataPoints": 3, "notes": "The slide uses a Q&A transcript format to expose flaws in clinical trial integrity.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/319", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-319", "components": [ { "bbox": null, "kind": "callout", "text": "Trial investigator #5 highlighted the enormous discontinuation rate close to 80%, and admitted that the trials were basically unblinded because the side effects were so obvious and significant.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-70f3-714d-84c4-3f0d76969d69", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.72, "x": 0.07, "y": 0.34 }, "kind": "list", "text": "High discontinuation rate; hairiness unblinded the trial; patients continued to gain weight on drug", "attrs": null, "subkind": "bullet", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "d9bc1db7-8143-4608-a805-4a26e1b89a4c", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "metric", "text": "discontinuation rate: 80%", "attrs": null, "subkind": "primary", "toolName": "Quantification", "toolSlug": "quantification", "confidence": null, "componentId": "019dd953-70f3-714d-84c4-456f7a378a2a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.08, "w": 0.86, "x": 0.07, "y": 0.22 }, "kind": "paragraph", "text": "The reasons for discontinuation included serious adverse effects, continued weight gain, and general lack of patient enthusiasm – “one individual continued to gain weight while on drug...she probably got randomized to real drug...because she got hairy...so I was pretty sure she on real drug...”", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "9273d114-bb81-49ca-9270-c33b52064e88", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.48, "w": 0.86, "x": 0.07, "y": 0.39 }, "kind": "paragraph", "text": "Q: “How many patients did you enroll?”\nA: “I want to say maybe [redacted - approximately 10]. One patient had to be withdrawn because he developed [redacted]...so we blamed it on the drug and took him off the study. Another patient dropped out for family reasons. A couple of patients continued on through C-601 and entered the open label and stayed on drug for a variable amount of time before they dropped off. And then I have two who are continuing and are now transitioning to commercial supply.”\nQ: ‘So, two out of [redacted - approximately 10] stayed on it, basically.”\nA: “...one individual continued to gain weight while on drug. She probably got randomized to real drug at the beginning because she got hairy. And so, I was pretty sure she was on real drug, but even so, she continued to gain weight. And she stayed on drug for a period of time after going to open label. But ultimately, after a year or two, her family wanted to enroll her in an inpatient program. And so, they withdrew her from the study.”\nQ: “And so, of the [redacted number of total trial enrollees]— and this was how many years ago that you enrolled the eight? How long ago?”\nA: “It’s probably three years now.”\nQ: “And now, three years later, of those, how many of them like the drug enough to still be on it? What’s the continuation rate?”\nA: “Well, two.”\nQ: “So, it’s got an approximately 75% discontinuation rate.”\nA: “Well, one of them was discontinued for [redacted].” -Trial investigator, pediatrician/geneticist, professor", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e737549d-871a-40d6-b0ba-dd7bbafcf952", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“one individual continued to gain weight while on drug...she probably got randomized to real drug...because she got hairy...so I was pretty sure she on real drug...” — Trial investigator, pediatrician/geneticist, professor", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-70f3-714d-84c4-4100415da407", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.31, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "5b2db353-2a0b-4808-8be0-505746587380", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.15, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Trial investigator #5 highlighted the enormous discontinuation rate close to 80%, and admitted that the trials were basically unblinded because the side effects were so obvious and significant.", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "1bc0009a-f372-42a4-a09d-676e1369bb01", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [ { "name": "fraud-exposure", "slug": null, "matchId": "2978317c-cb1e-4d9d-a81d-534ea0ff776f", "evidence": "Uses expert testimony to highlight trial failure and unblinding.", "confidence": 0.9 } ], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }