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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "All I’ve seen are the summary stats...I haven’t seen anything on an individual basis...so yeah, it does worry me that things are not published, for sure...and there are odd things like the papers don’t describe insulin resistance at all anywhere...something very weird going on...their leptin goes massively down despite there not being a huge change in fat mass...something odd there...they haven’t really shown that insulin resistance gets bigger...they don’t report...and I don’t know why.",
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      "text": "Investigator concerned at lack of withdrawal study publication paper; \"odd things\"; \"something very weird\"; lack of reporting on insulin resistance calls the purported mechanism of action into count",
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      "text": "Q: \"The weird thing I noticed is, given that randomized withdrawal study was the basis of the FDA approval, when I looked for the paper, the paper is not available. They never published it.\" A: \"All I've seen are the summary stats...\"",
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      "text": "“All I’ve seen are the summary stats. I haven’t seen anything on an individual basis. So yeah, it does worry me that things are not published, for sure. And, there are odd things like the papers don’t describe insulin resistance at all anywhere. They talk about glucose and insulin levels, but no one’s actually reported the insulin resistance because one would expect the insulin levels go down and the leptin really goes down. And there’s something very weird going on. Their leptin goes massively down despite there not being a huge change in fat mass. So, there’s something odd there. And then, mechanistically, they haven’t really shown that insulin resistance gets bigger. They don’t report. And I don’t know why.” — Trial investigator; endocrinologist; one of the most published authorities on PWS and hyperphagia",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #4 expressed suspicion and concern about Soleno’s behavior given the lack of a published paper for the withdrawal study which was the basis of Vykat’s FDA approval; missing data that he expected to be reported; and strange discrepancies and contradictions in the data they did report",
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