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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "The investigator thrashed Vykat as an utter failure on all counts with a 100% patient discontinuation rate – \"none of mine continued on it either because they didn't want to or not having much effect - overall this isn't a miracle drug, that's for sure\"; \"they stopped it because they just didn't see any benefit...it wasn't doing much and they were still very obese...they didn't feel it worthwhile with the ongoing assessments and all the rest of it...the benefits were not seen to be good enough to continue on it.\"",
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      "text": "Leading PWS authority and trial investigator; 75 PWS patients\nAround 10 patients in the trials; 100% discontinuation rate; “this isn’t a miracle drug, that’s for sure”\nPatients discontinued because “just didn’t see any benefit from it”; “still very obese”; didn’t feel it was worth it to even come in for trial assessments",
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      "text": "Q: “How many patients did you you enroll in the trial?”\nA: “Under 10. I have a pediatric colleague who I work with who comes to my clinic. She has more on. I’ve heard about her experience from it as well. I’ve got a little bit more feedback from it. It’s an allied institution.”\nQ: “Between you and the allied institution, was it under 10 or was it over 10?”\nA: “It was probably around just over ten, I think.”\nQ: “And so it sounds like you basically have a 100% discontinuation rate if nobody’s still on it?”\nA: “Yeah. None of mine continued on it either because they didn’t want to or not having much effect…overall, this isn’t a miracle drug, that’s for sure.” –Trial investigator; one of the most published authorities on PWS and hyperphagia\nQ: “Let’s talk about the discontinuation rate of the patients that you enrolled. What were their rough ages? How quickly did they start rolling off? How long did the longest one stay on it?”\nA: “They stopped because they just didn’t see any benefit from it….I’ve just actually just started them on GLP-1. And we’re waiting to see if they do better on that than they did on — they came off it because it wasn’t doing much and they were still very obese and they couldn’t be on the GLP along with the DCCR. So, they had to stop…I think part of the problem was the ongoing trial visits, and they didn’t feel it worthwhile with the ongoing assessments and all the rest of it…it was just that the benefits were not seen to be good enough to continue on it.” –Trial investigator; one of the most published authorities on PWS and hyperphagia",
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      "text": "“none of mine continued on it either because they didn’t want to or not having much effect – overall this isn’t a miracle drug, that’s for sure”; “they stopped it because they just didn’t see any benefit...it wasn’t doing much and they were still very obese...they didn’t feel it worthwhile with the ongoing assessments and all the rest of it...the benefits were not seen to be good enough to continue on it.”",
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      "text": "\"None of mine continued on it either because they didn't want to or not having much effect...overall, this isn't a miracle drug, that's for sure.\" — Trial investigator; endocrinologist; one of the most published authorities on PWS and hyperphagia",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #4: An endocrinologist who is a globally-recognized authority on PWS with ~75 patients; participated in the phase 3, open-label, and withdrawal study with ~10 patients enrolled. The investigator thrashed Vykat as an utter failure on all counts with a 100% patient discontinuation rate",
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