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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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      "text": "But here, in a way, you’ve got the worst of both worlds. You’ve got a drug that doesn’t seem to be very effective in controlling hyperphagia, and it has a risk of elevating blood sugars.",
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      "text": "One patient experienced hyperglycemia; diabetes risk and lack of effectiveness are “worst of both worlds”\nA: “We had to pause one person whose blood sugar levels got a bit out of control.”\nQ: “I noticed in the pilot study, there were 13 people. One of them became a full-blown diabetic. Others seemed to become pre-diabetic. I think 30%, 40% of patients in this population are diabetic. Does that create a massive risk or at least limit the treatable population?”\nA: “I think that's right. Here’s a population that is very at risk for diabetes. To some extent, obviously, if either you keep the weight under control through food controls or you’ve got a drug that’s effective, then it's less of a problem. But here, in a way, you’ve got the worst of both worlds. You’ve got a drug that doesn’t seem to be very effective in controlling hyperphagia, and it has a risk of elevating blood sugars.” - Trial investigator, key opinion leader for PWS",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #3 stated that he had to “pause one person whose blood sugar levels got a bit out of control” and expressed concern at Vykat’s diabetes risk profile – “here’s a population that is very at risk of diabetes…here, in a way, you’ve got the worst of both worlds…you’ve got a drug that doesn’t seem to very effective in controlling hyperphagia, and it has a risk of elevating blood sugars.”",
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