{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 307, "pageCount": 415, "prevPage": 306, "nextPage": 308, "slideType": "quote_slide", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide uses a Q&A format to highlight the investigator's skepticism.", "elementsJson": [ "headline_text", "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/307", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-307", "components": [ { "bbox": null, "kind": "callout", "text": "I actually thought it probably wouldn’t be approved...I thought they would be much tougher...and I think there was a very powerful campaign [by associations/families]...families are desperate to see treatment.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2b0-0f8cda17f936", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.06, "w": 0.86, "x": 0.07, "y": 0.34 }, "kind": "paragraph", "text": "Skeptical of withdrawal study data; didn’t think drug would be approved; only approved because of pressure campaign by desperate families", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "c026ff8e-ef56-4657-a865-2027564858b5", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.45, "w": 0.86, "x": 0.07, "y": 0.41 }, "kind": "quote", "text": "Q: “The withdrawal study data seems too good to be true. You have patients that have been on a drug for years, and just immediately after they go on placebo, the HQ-CT score spikes like a hockey stick. And these are not patients that are naive to the drug. And the most amazing thing there is they never published a paper for that randomized withdrawal study. They've buried it.”\nA: “Yes, yes, yes.”\nQ: “Did you take note of the fact that they never published that paper? The paper that is the basis of FDA approval.”\nA: “I actually thought it probably wouldn’t be approved. I thought they would be much tougher. And I think there was a very powerful campaign [by associations/families].”\nQ: “You mean using the patient support groups?”\nA: “Yes. I think one of the issues here is that families are desperate to see treatment for hyperphagia and also for some of the other problem behaviors...hopes have been raised in previous trials and then shattered, and then other trials, as I say, they've been stopped because either the funding ran out or there wasn't real convincing evidence of efficacy or whatever. An enormous amount was invested in this trial. And in a sense, it's the first trial that got to the stage, got close enough to being considered for FDA approval. And I think people felt, and understandably, felt that the treatment was needed. This is the sort of consequences of that.” - Trial investigator, key opinion leader for PWS", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "8889a50d-4a0b-457c-95c2-293e5a5eb06c", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "“Yes, yes, yes.” — Trial investigator, key opinion leader for PWS; “I actually thought it probably wouldn’t be approved. I thought they would be much tougher. And I think there was a very powerful campaign [by associations/families].” — Trial investigator, key opinion leader for PWS", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2b0-125ce4310046", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.25, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "35a7c217-4734-4c5f-bd5e-4d8458c2ef6f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.22, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "Trial investigator #3 expressed strong concerns about the validity and conduct of the trials, in particular the withdrawal study which was the basis of FDA approval. He replied “yes, yes, yes” when we stated that the withdrawal study data seemed too good to be true – “I actually thought it probably wouldn’t be approved...I thought they would be much tougher...and I think there was a very powerful campaign [by associations/families]...families are desperate to see treatment.”", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "218efda8-4573-489b-9fbc-1a0ed975da3a", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [ { "name": "fraud-exposure", "slug": null, "matchId": "9b092d4c-992e-4940-ad6a-132e82e6303e", "evidence": "The slide explicitly frames the investigator's testimony to expose potential misconduct or lack of validity in the FDA approval process.", "confidence": 0.9 } ], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }