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  "documentTitle": "Soleno Therapeutics (SLNO)",
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      "text": "to be frank, my feeling was I don't think anyone improved",
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      "text": "PI doesn't think \"anyone improved\" and is \"very skeptical\"; patients still hyperphagic and gaining weight on drug; also aware who was on drug and therefore unblinded",
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      "text": "Q: \"What was your impression of the [approximately 5] patients that you put in the trial? Did you think it worked? Did they stay on it? What are your observations?\" A: \"I'm happy to talk about that...to be frank, my feeling was that I don't think anyone improved...\"",
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      "text": "“to be frank, my feeling was I don't think anyone improved”; “so, I have been very skeptical about it”; “we knew he was on DCCR – and he put on a lot of weight...so clearly, this was not effective”; “then another person on the trial, she was putting on weight” — Trial investigator, key opinion leader for PWS",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #3 stated none of his patients improved and in fact tended to keep gaining weight, and that other patients just dropped out. He further indicated that the trial was functionally unblinded due to obvious side effects",
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