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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses direct quotes from a trial investigator to undermine the drug's market potential and clinical efficacy.",
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      "text": "I would be very surprised if it's a blockbuster, and if it was, it would be on the back of the hype and the sense of need, not on the basis of effectiveness...the risk of elevated blood sugars or worth the risk of hair growth or whatever it is — that I would struggle with.",
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      "text": "Not a blockbuster drug; any potential is based on desperation not effectiveness; other PI's share same opinion; concerned about hyperglycemia",
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      "text": "“I would be very surprised if it's a blockbuster, and if it was, it would be on the back of the hype and the sense of need, not on the basis of effectiveness...there have been others who clearly feel closer to how I have felt about it. I haven't had a sense of an absolutely glowing endorsement...it's not going to remove the need for controlling access to food....the risk of elevated blood sugars or worth the risk of hair growth or whatever it is — that I would struggle with.” - Trial investigator, key opinion leader for PWS",
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      "text": "“My own feeling and from our own research, I feel that a treatment is possible, but I don’t think it’s this treatment...it’s just that the satiety system in people with Prader-Willi Syndrome is very inefficient. What you’ve got to do is find something that makes it more efficient. You can bring about satiety in people with Prader-Willi Syndrome if you allow them to have enough food. That just happens to be far too much. You’ve got to try and improve efficiency. And I think Vykat doesn’t do that.” - Trial investigator, key opinion leader for PWS",
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      "text": "\"I would be very surprised if it's a blockbuster, and if it was, it would be on the back of the hype and the sense of need, not on the basis of effectiveness...there have been others who clearly feel closer to how I have felt about it. I haven't had a sense of an absolutely glowing endorsement...it's not going to remove the need for controlling access to food....the risk of elevated blood sugars or worth the risk of hair growth or whatever it is — that I would struggle with.\" — Trial investigator, key opinion leader for PWS; \"My own feeling and from our research, I feel that a treatment is possible, but I don't think it's this treatment...it's just that the satiety system in people with Prader-Willi Syndrome is very inefficient. What you've got to do is find something that makes it more efficient. You can bring about satiety in people with Prader-Willi Syndrome if you allow them to have enough food. That just happens to be far too much. You've got to try and improve efficiency. And I think Vykat doesn't do that.\" — Trial investigator, key opinion leader for PWS",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #3 stated that Vykat is a total failure with no impact on hyperphagia or weight. He expressed surprise that the FDA approved it, attributing it to families’ desperation and “hype” and “not on the basis of effectiveness”; indicated that other investigators and PWS KOL’s in general share his skepticism; and he “would struggle with” the risk of diabetes and other serious adverse effects – “I would very surprised if it’s a blockbuster”; “others who clearly feel closer to how I have felt about it”; “I feel that a treatment is possible, but I don’t think it’s this treatment…Vykat doesn’t do that.”",
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      "text": "Vykat has no impact on hyperphagia or satiety",
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