{
  "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583",
  "docSlug": "f06b0b5d2079",
  "documentTitle": "Soleno Therapeutics (SLNO)",
  "authorId": "58_Scorpion_Capital",
  "authorName": "Scorpion Capital",
  "documentKindSlug": "activist-deck",
  "documentKindLabel": "Activist deck",
  "sourceTypeSlug": "short_seller",
  "sourceTypeLabel": "Short seller",
  "presentationDate": "2025-08-15 00:00:00",
  "orientation": "landscape",
  "aspectRatio": 1.3333334,
  "pageNumber": 291,
  "pageCount": 415,
  "prevPage": 290,
  "nextPage": 292,
  "slideType": "expose_contradiction",
  "function": "expose_contradiction",
  "density": "overcrowded",
  "nDataPoints": 0,
  "notes": "Uses direct quotes from a trial investigator to undermine the validity of clinical trial data.",
  "elementsJson": [
    "paragraph",
    "quote_block"
  ],
  "metadataConfidence": 1,
  "imagePath": null,
  "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/291",
  "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583",
  "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json",
  "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-291",
  "components": [
    {
      "bbox": null,
      "kind": "callout",
      "text": "He indicated he did not observe a hyperphagia improvement in patients, and that parental hyperphagia assessments were in conflict and thus unreliable as the primary endpoint.",
      "attrs": null,
      "subkind": null,
      "toolName": "Visual emphasis",
      "toolSlug": "visual-emphasis",
      "confidence": null,
      "componentId": "019dd953-64ce-7561-b2af-42bcd1957e6c",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.86,
        "x": 0.07,
        "y": 0.38
      },
      "kind": "paragraph",
      "text": "Parents appeared to inflate baseline hyperphagia scores out of “desperation” to enroll their children",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "1b132bd2-82cd-4ccd-88ac-ebd9e1156e45",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.03,
        "w": 0.86,
        "x": 0.07,
        "y": 0.63
      },
      "kind": "paragraph",
      "text": "Did not observe a hyperphagia improvement in patients; parental assessments were in conflict and unreliable",
      "attrs": null,
      "subkind": "paragraph",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "3d6c00d1-1c1f-483e-9e42-3e405fa3e3b7",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.18,
        "w": 0.86,
        "x": 0.07,
        "y": 0.41
      },
      "kind": "quote",
      "text": "“I think we found out that, in my opinion, some of the people coming in knew what they should be looking for as far as the scores on the questionnaire form. So, they come in 13, 13, 13, after you get three or four 13s, I said, well, why are we all getting 13? Somewhere along, I'm thinking, my opinion, because these are young families are on Facebook, they probably knew they had a certain score that the child had to have before they could enter the trial. Everyone had run that score. I thought that was so strange. It's got what? Zero, three, six, and then 13 is a cutoff. And they're 13, 13, 13. . It's human nature, right? You're a parent. You're desperate. You want to do anything for your child, and you want to make sure the child. But when you do that, then you're stuck with that trial. You can't do another trial because you're enrolled in a trial, and you're keeping that trial for five years, you'll never get a chance to have your child in another trial that may or may not be more productive as far as treatment.” -Trial investigator and physician; one of the leading KOL's in the PWS field",
      "attrs": null,
      "subkind": "testimonial",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "2d71729c-41ab-49e8-b4d2-fa00c5ba45b0",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.22,
        "w": 0.86,
        "x": 0.07,
        "y": 0.66
      },
      "kind": "quote",
      "text": "Q: “It sounds like you did not observe a meaningful change in the [redacted] patients you enrolled. Is that correct? Even though the survey might have shown it?”\nA: “Correct. My information is based on what mom and dad tell me. I don't live with these kids. Right? I see them once every three months. When they ask, okay, do you think there's a different hyperphagia? The child's not eating. How am I supposed to, as a clinician, how am I supposed to determine hyperphagia? I don't see the patient eating. So, I have to base my decision on what mom and dad tell me. Dad tells me one time. Mom tells me the next clinic visit. They may not be in agreement. So, I get different conflicting answers, right? So, how am I supposed to make a decision as a clinician based on subjectivity?” - Trial investigator and physician; one of the leading KOL's in the PWS field",
      "attrs": null,
      "subkind": "testimonial",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "d9d8dd24-e851-481a-ab15-2035d217b5df",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": null,
      "kind": "quote",
      "text": "“I think we found out that, in my opinion, some of the people coming in knew what they should be looking for as far as the scores on the questionnaire form. So, they come in 13, 13, 13, after you get three or four 13s, I said, well, why are we all getting 13? ... You're desperate. You want to do anything for your child... It's human nature, right?” — Trial investigator and physician; one of the leading KOL's in the PWS field",
      "attrs": null,
      "subkind": null,
      "toolName": "Authority citation",
      "toolSlug": "authority-citation",
      "confidence": null,
      "componentId": "019dd953-64ce-7561-b2af-4751ffd980cc",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.02,
        "w": 0.3,
        "x": 0.07,
        "y": 0.95
      },
      "kind": "source-note",
      "text": "Source: Scorpion Capital consultation calls with experts",
      "attrs": null,
      "subkind": null,
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "0e0a46a9-45bc-4ab3-9c73-b4108ab4185f",
      "frameworkName": null,
      "frameworkSlug": null
    },
    {
      "bbox": {
        "h": 0.25,
        "w": 0.86,
        "x": 0.07,
        "y": 0.07
      },
      "kind": "title",
      "text": "Trial investigator #1 stated that parents simply filled out their children’s hyperphagia questionnaires to match the entry criteria, thus inflating the baseline scores: “we found out that...some of the people coming in knew what they should be looking for as far as the scores...so they come in 13, 13, 13...I said, well, why are well getting 13?...I thought that was so strange...you’re a parent...you’re desperate.” He indicated he did not observe a hyperphagia improvement in patients, and that parental hyperphagia assessments were in conflict and thus unreliable as the primary endpoint.",
      "attrs": null,
      "subkind": "headline",
      "toolName": null,
      "toolSlug": null,
      "confidence": null,
      "componentId": "181a7e2e-5bad-414c-bdfc-7709070c3aa4",
      "frameworkName": null,
      "frameworkSlug": null
    }
  ],
  "metrics": [],
  "tools": [],
  "frameworks": [
    {
      "name": "fraud-exposure",
      "slug": null,
      "matchId": "173cade5-c7c5-4216-80b7-65b655f8eeef",
      "evidence": "Exposing unreliable clinical trial data through investigator testimony",
      "confidence": 0.9
    }
  ],
  "arcBeats": [],
  "loops": [],
  "imagePathAlt": null,
  "thumbSrc": null,
  "thumbSrcAlt": null,
  "locked": true
}