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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "notes": "The slide uses a Q&A format to highlight allegations of 'artificial enrollment' and data manipulation.",
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      "text": "I think it was artificial enrollment because it was based on subjectivity enrollment.",
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      "text": "Trial investigator #1 stated that the FDA should not have approved Vykat and expressed surprise that they had done so, indicating it was due to pressure from desperate families in PWS associations: “I was kind of surprised...a lot of that’s driven by the young families that have Facebook.” He dismissed the trial as fatally flawed due its subjective endpoint based on a hyperphagia questionnaire. He indicated that that parents inflated hyperphagia baseline scores to get into the trial – “it was artificial enrollment”; and that the scores were useless as they fluctuated dramatically depending on who filled out the form: “when dad fills out the form, you get a 30% different answer than when mom fills out the form on the same child.”",
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      "text": "Surprised Vykat got approved by FDA; pushed by patient associations... [Q&A transcript excerpts]",
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      "text": "I was kind of surprised...a lot of that’s driven by the young families that have Facebook. And they’re very active...And they’re much more convinced they’re going to cure this condition in their child’s lifetime. — Trial investigator and physician; one of the leading KOL’s in the PWS field",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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