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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "Uses Q&A format to highlight expert skepticism and safety concerns.",
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      "text": "It looks like a substantial percentage of patients became diabetic or pre-diabetic. It almost seems like the mechanism of action of this drug is induced diabetes.",
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      "text": "PWS patients typically on multiple other drugs that are also diabetogenic",
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      "text": "Taking wait and see attitude due to safety concerns like diabetes",
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      "text": "Trial investigator #1 indicated additional fear about Vykat-induced diabetes, commenting on the drug's mechanism of action: \"it certainly is involved with insulin and glucose...that's interesting, isn't it? I've been around a long time, five decades of work in this area, that I want to take a wait and see attitude...we had 100 patients [in the trial]...six months from now, we'll know more, won't we?\" He added that PWS patients are typically on multiple other drugs that are also diabetogenic, thereby compounding the risk. Most PWS patients are on growth hormone which \"we know can cause issues with blood sugar...other drugs like risperidone that can interfere with blood sugar...there are some drugs that can be diabetogenic.\"",
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      "text": "“Well, that's interesting, isn't it? I've been around a long time, five decades of work in this area, that I want to take a wait and see attitude. Now, these are the things we have to look out for, don't we? We have 100 patients [in the trial]...six months from now, we'll know more, won't we?” — Trial investigator and physician; one of the leading KOL's in the PWS field",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "Trial investigator #1 indicated additional fear about Vykat-induced diabetes",
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