{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 257, "pageCount": 415, "prevPage": 256, "nextPage": 258, "slideType": "quote_slide", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide uses a Q&A format to present expert testimony that undermines the value proposition of the drug Vykat.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 0.95, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/257", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-257", "components": [ { "bbox": null, "kind": "callout", "text": "The KOL expressed cynicism about the Vykat’s label’s “interesting claim” to not substitute inexpensive diazoxide suspension; questioned why anyone would pay for Vykat versus using the suspension; and expressed “amazement” that ChatGPT spits out an equivalent dosing table for suspension vs. Vykat", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2ac-1a4c59df2a7a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.42 }, "kind": "paragraph", "text": "Questioned the label's claim about generic substitution; “amazed” at ChatGPT equivalent dosing tables for generic vs. Vykat\nQ: “And so then I went to ChatGPT and I said, is the oral and the extended-release the same pharmacokinetic profile? And they essentially are. And diazoxide has a very long half-life, which means that it would just take a couple of days longer for somebody on the oral solution to get to the same steady state plasma level of diazoxide. Then ChatGPT spit out the formula. It said, okay, well, here is the equivalent dose of oral that matches the three tablet weights for DCCR.”", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "9f83b38d-28f9-4bad-8d3b-f49baaecd903", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.53 }, "kind": "quote", "text": "A: “[Laughs] Wow! it says in the label, like I literally saw it said, please do not use diazoxide oral suspension in place of Vykat XR as, like, steady state, half-life, all those things are different. But again, it's a known drug. It's been around forever. So, why would you pay that kind of money? At some point, people may start to — I mean the fact that you can like ask ChatGPT, that's amazing to me. I'm obviously old, and I wouldn't have even thought of that. It's amazing that you can do that. And it literally gives you the actual formula to dose...I wrote, hmm. That's an interesting claim to make...” – KOL in the PWS field; involved with Soleno's clinical program", "attrs": null, "subkind": "testimonial", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "241eaa0e-bef1-42e8-a7b1-4775cbf3cbe4", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "[Laughs] Wow! it says in the label, like I literally saw it said, please do not use diazoxide oral suspension in place of Vykat XR as, like, steady state, half-life, all those things are different. But again, it’s a known drug. It’s been around forever. So, why would you pay that kind of money? At some point, people may start to — I mean the fact that you can like ask ChatGPT, that’s amazing to me. I’m obviously old, and I wouldn’t have even thought of that. It’s amazing that you can do that. And it literally gives you the actual formula to dose...I wrote, hmm...that’s an interesting claim to make.” — KOL in the PWS field; involved with Soleno’s clinical program", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2ac-1c3f4aeb584a", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.03, "w": 0.3, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "d7f2082a-436c-4045-874a-5d827b2c4e9f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "The KOL expressed cynicism about the Vykat’s label’s “interesting claim” to not substitute inexpensive diazoxide suspension; questioned why anyone would pay for Vykat versus using the suspension; and expressed “amazement” that ChatGPT spits out an equivalent dosing table for suspension vs. Vykat", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "e2be421f-fa7f-48e0-965b-4489ccfa7025", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }