{ "docId": "019dd923-622c-750b-8b9a-3bcd52c6e583", "docSlug": "f06b0b5d2079", "documentTitle": "Soleno Therapeutics (SLNO)", "authorId": "58_Scorpion_Capital", "authorName": "Scorpion Capital", "documentKindSlug": "activist-deck", "documentKindLabel": "Activist deck", "sourceTypeSlug": "short_seller", "sourceTypeLabel": "Short seller", "presentationDate": "2025-08-15 00:00:00", "orientation": "landscape", "aspectRatio": 1.3333334, "pageNumber": 250, "pageCount": 415, "prevPage": 249, "nextPage": 251, "slideType": "expose_contradiction", "function": "expose_contradiction", "density": "dense", "nDataPoints": 0, "notes": "The slide uses direct quotes from a KOL to undermine the credibility of the clinical trial results.", "elementsJson": [ "paragraph", "quote_block", "footnote" ], "metadataConfidence": 1, "imagePath": null, "slideHref": "/slides/019dd923-622c-750b-8b9a-3bcd52c6e583/250", "deckHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583", "deckJsonHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583.json", "deckAnchorHref": "/decks/019dd923-622c-750b-8b9a-3bcd52c6e583#slide-250", "components": [ { "bbox": null, "kind": "callout", "text": "The KOL blasted the entire package of Vykat clinical trials as lacking in credibility and alleged a pattern on dubious investigator conduct, from the single-center Phase 2 pilot study to the randomized withdrawal trial that kicked it over the finish line.", "attrs": null, "subkind": null, "toolName": "Visual emphasis", "toolSlug": "visual-emphasis", "confidence": null, "componentId": "019dd953-64ce-7561-b2ab-a01d3150f014", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.12, "w": 0.86, "x": 0.07, "y": 0.63 }, "kind": "paragraph", "text": "Studies were done “poorly”; management allegedly aware of the problems\n“I was just struck with how poorly the study was done. Just that the investigator was cutting corners, doing stuff that didn't meet GCP, like, people are out of a window. And it was weird stuff. And I was just like, wow. So that was definitely a problem.” – KOL in the PWS field; involved with Soleno's clinical program", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "0ecddf69-8404-46d9-a400-c75492d86599", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.18, "w": 0.86, "x": 0.07, "y": 0.41 }, "kind": "paragraph", "text": "Pilot study had “very dirty data”; “cutting corners”\n“I looked at that data before they published it, and it was very dirty data. I don't know who runs a study like this where people aren't in-window and there's all these problems. Like, I kept seeing issues and I was like, how did you guys not have more oversight of one single investigator who's cutting corners and just doing stuff that generally is not okay? But, they had to go with the horse they rode in. And so that's what they did. And the Phase 2 trial was also pretty small, and, again, running just a few sites.” – KOL in the PWS field; involved with Soleno's clinical program", "attrs": null, "subkind": "paragraph", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "ca0542bc-703c-414c-892c-fb3386f58d36", "frameworkName": null, "frameworkSlug": null }, { "bbox": null, "kind": "quote", "text": "I looked at that data before they published it, and it was very dirty data. I don't know who runs a study like this where people aren't in-window and there's all these problems. Like, I kept seeing issues and I was like, how did you guys not have more oversight of one single investigator who's cutting corners and just doing stuff that generally is not okay? But, they had to go with the horse they rode in. And so that's what they did. And the Phase 2 trial was also pretty small, and, again, running just a few sites. — KOL in the PWS field; involved with Soleno's clinical program", "attrs": null, "subkind": null, "toolName": "Authority citation", "toolSlug": "authority-citation", "confidence": null, "componentId": "019dd953-64ce-7561-b2ab-a788873a233f", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.02, "w": 0.25, "x": 0.07, "y": 0.95 }, "kind": "source-note", "text": "Source: Scorpion Capital consultation calls with experts", "attrs": null, "subkind": null, "toolName": null, "toolSlug": null, "confidence": null, "componentId": "2dfa32fa-2255-4e2f-b3ad-6adf457d7fde", "frameworkName": null, "frameworkSlug": null }, { "bbox": { "h": 0.25, "w": 0.86, "x": 0.07, "y": 0.07 }, "kind": "title", "text": "The KOL blasted the entire package of Vykat clinical trials as lacking in credibility and alleged a pattern on dubious investigator conduct, from the single-center Phase 2 pilot study to the randomized withdrawal trial that kicked it over the finish line. The KOL stated the pilot study “was very dirty data...I don’t know who runs a study like this where people aren’t in-window and there’s all these problems...I kept seeing issues...I was like, how did you guys not have more oversight of one single investigator who’s cutting corners and just doing stuff that is generally not ok?”; “I was just struck at how poorly the study was done...it was weird stuff...I was just like, wow..\"", "attrs": null, "subkind": "headline", "toolName": null, "toolSlug": null, "confidence": null, "componentId": "a1b93b76-9acb-47d4-8066-f80f8fe69c11", "frameworkName": null, "frameworkSlug": null } ], "metrics": [], "tools": [], "frameworks": [ { "name": "antagonist-introduction", "slug": null, "matchId": "4f1ea7c4-44f6-4f0f-80f2-4d731f940246", "evidence": "Uses KOL testimony to frame the company's clinical trials as fraudulent or incompetent.", "confidence": 0.9 } ], "arcBeats": [], "loops": [], "imagePathAlt": null, "thumbSrc": null, "thumbSrcAlt": null, "locked": true }