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      "text": "Concerned about high drop out rate due to serious side effects",
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      "text": "Data that is missing suggests an attempt to downplay diabetes risk and to cover up lack of effectiveness",
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      "text": "Q: “Was there anything in the data or the methodology for the randomized withdrawal that jumped out at you the way they did it that led you to think that?” A: “It was really just how many people had dropped out from the time they started to the time they did that. I just think that’s interesting. And I just pulled it out because I thought it was so interesting. One paragraph in the labeling says people who discontinued the study dropped out due to treatment compared to placebo, not the randomized withdrawal, mind you, increased hyperphagia, type 2 diabetes, pulmonary edema, aggression, anger, labile effect, and hoarding and suicidal ideation. I don’t know. I find that to be pretty significant side effects. So, that was my issue is that —” - KOL in the PWS field; involved with Soleno’s clinical program",
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      "text": "Q: “Is their diabetes data accurate? I’ve had a couple of promotional trial investigators say, oh, well, the blood sugar went up five points. It didn’t really concern me that much, fasting glucose. That seems to me to be really downplaying it, given the mechanism of action. Is that accurate? Or do you think it’s gone up more?” A: “People dropped out because they got diabetes, and they dropped out because they got blood sugar issues. The deal is, I’m sure that is probably minimizing what really happened. But again, I think what they didn’t say is just as interesting as what they did say. There are some things that are missing, that if it was that great, you would think they would be talking about it, and they’re not.” - KOL in the PWS field; involved with Soleno’s clinical program",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "The KOL pointed to the massive dropout rate in the trials as a red flag consistent with the drug’s toxicity profile, when we asked what jumped out in the data – “just how many people had dropped out...I just think that’s interesting...one paragraph in the labeling says people...dropped out due to...increased hyperphagia, type 2 diabetes, pulmonary edema, aggression, anger, labile effect, and hoarding and suicidal ideation...I find that to be pretty significant side effects”; “people dropped out because they got diabetes...and...they got blood sugar issues...I’m sure that is probably minimizing what really happened...again, what they didn’t say is just as interesting as what they did say....”",
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