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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "presentationDate": "2025-08-15 00:00:00",
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  "notes": "The slide uses direct quotes from a Key Opinion Leader (KOL) to build a case against the drug's safety and market viability.",
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      "kind": "callout",
      "text": "Skeptical of significant side effect profile – diabetes, ketoacidosis, edema; endocrinologist uncomfortable prescribing",
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      "text": "Highly skeptical of real-world “fallout” as drug is introduced vs. minor statistical artifact in trial",
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      "text": "The KOL characterized Vykat as a total flop and exhibited concern about a cover-up and misrepresentation of the drug’s toxicity profile – and fears a looming safety debacle as patients begin to trial it.",
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      "text": "Ominously, the KOL mentioned several leading PWS endocrinologists who are already refusing to use it – “a couple of endos who are telling me – it’s interesting – that they’re not comfortable prescribing it because of the side effect profile...I think that’s telling”; “five points [in the hyperphagia survey] is not a gigantic change...it’s going to be interesting when the fallout comes with people aren’t in the clinical trial...I think the jury’s definitely still out.” The KOL stated that “the side effect profile...that worries me...on multiple town halls and dissemination efforts by Soleno, a lot of side effects are not really being addressed...diabetic ketoacidosis, edema, fluid retention, peripheral and pulmonary edema, those are significant...I tell people, if your kid is already likely to have diabetes...we don’t know a ton about what this drug is going to do.”",
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      "text": "I do think the side effect profile is a little troubling. That worries me about some of the side effects and also the fact that, having been on multiple town halls and other dissemination efforts from Soleno, a lot of side effects are not really being addressed in a way — people are excited and there's obviously a lot of hype. And I tell people, if your kid is already likely to have diabetes...we don't know a ton about what this drug is going to do. And so I have talked to a couple of endos who are telling me — it's interesting — that they're not comfortable prescribing it because of the side effect profile. I think that's telling. — KOL in the PWS field; involved with Soleno's clinical program",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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      "text": "The KOL characterized Vykat as a total flop and exhibited concern about a cover-up and misrepresentation of the drug’s toxicity profile – and fears a looming safety debacle as patients begin to trial it.",
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