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  "documentTitle": "Soleno Therapeutics (SLNO)",
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  "authorName": "Scorpion Capital",
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  "presentationDate": "2025-08-15 00:00:00",
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      "text": "Impact of chronic diuretic treatment on glucose homeostasis\nConclusions\nThe use of diuretics is associated with insulin-resistance and serum uric acid levels and may contribute to abnormal glucose tolerance.",
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      "text": "Studies on diabetogenic effects of chronic diuretic use",
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      "text": "Source: https://www.ahajournals.org/doi/10.1161/hypertensionaha.108.114389; https://www.healthline.com/health/diabetes/how-diuretics-cause-hyperglycemia; https://pmc.ncbi.nlm.nih.gov/articles/PMC3880098/;",
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      "text": "How Do Diuretics Cause Hyperglycemia?",
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      "text": "Long-term, chronic-loop diuretic use in PWS is far from benign in patients taking diazoxide: electrolyte imbalances like hypokalemia (low potassium), hyponatremia (low sodium), and hypomagnesemia (low magnesium), all three of which can cause arrhythmia, QT prolongation, and worsened hypotonia, which is already present in PWS; and renal stress, as chronic diuretic therapy can cause pre-renal azotenia and acute kidney injury. In particular, diuretics are well-known in worsening hyperglycemia – creating synergistic risk as diazoxide mechanistically induces hyperglycemia as well. Moreover, PWS patients are on growth hormone (82%) and often on psychiatric medications like risperidone, both also diabetogenic – thus creating a mind-boggling cocktail of 4 diabetogenic drugs in PWS patients already prone to obesity.",
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      "text": "Thiazide-Induced Dysglycemia",
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