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      "text": "Phase 3 was a “cherry-picking exercise” with a post-hoc subgroup analysis, “quite underwhelming”; “big safety signal as well”",
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      "text": "Dubious trial design weighted toward a single questionable trial site; “soft endpoint”; lack of objective endpoints in the label claims; lack of confirmatory behavioral changes; serious risk of diabetes and need for titration",
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      "text": "So, when you have a soft endpoint like this and it's not 100% backed up by some of the other objective endpoints... It boils down to a very soft hyperphagia questionnaire.",
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      "text": "Phase 3 was a “cherry-picking exercise” with a post-hoc subgroup analysis, “quite underwhelming”; “big safety signal as well”",
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      "text": "DEXA data was useless. You can also ask for the DEXA scan data because that for fat mass theoretically should not lie. I know that for one of the trials, they were not able to manage the data too well because they didn't set standards.",
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      "text": "“So, when you have a soft endpoint like this and it's not 100% backed up by some of the other objective endpoints, like, say, a DEXA scan to show improvement in fat and fat muscle ratio has changed or the HOMA-IR is overall trending downwards or unchanged for a metabolic signal. I was kind of a little surprised that they didn't have any of that as label claims.” — Ex-Soleno employee #1, key role in clinical trial program",
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      "text": "Source: Scorpion Capital consultation calls with experts",
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